Antimicrobial efficacy and toxicity of novel CAMPs against P. aeruginosa infection in a murine skin wound infection model

Antimicrobial efficacy and toxicity of novel CAMPs against P. aeruginosa infection in a murine skin wound infection model

Abstract Background Treatment of P. aeruginosa wound infection is challenging due to its inherent and acquired resistance to many conventional antibiotics. Cationic antimicrobial peptides (CAMPs) with distinct modes of antimicrobial action have been considered as the next-generation therapeutic agen...

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Bibliographic Details
Main Authors: Ming Yang, Chunye Zhang, Sarah A. Hansen, William J. Mitchell, Michael Z. Zhang, Shuping Zhang
Format: Article
Language:English
Published: BMC 2019-12-01
Series:BMC Microbiology
Subjects:
Cationic antimicrobial peptides
Toxicity
Antimicrobial activity
Pseudomonas aeruginosa
Mouse model
Skin infection
Online Access:https://doi.org/10.1186/s12866-019-1657-6

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