LncRNAs associated with glioblastoma: From transcriptional noise to novel regulators with a promising role in therapeutics

LncRNAs associated with glioblastoma: From transcriptional noise to novel regulators with a promising role in therapeutics

Glioblastoma multiforme (GBM) is the most widespread and aggressive subtype of glioma in adult patients. Numerous long non-coding RNAs (lncRNAs) are deregulated or differentially expressed in GBM. These lncRNAs possess unique regulatory functions in GBM cells, ranging from high invasion/migration to...

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Main Authors: Bhupender Yadav, Sonali Pal, Yury Rubstov, Akul Goel, Manoj Garg, Marat Pavlyukov, Amit Kumar Pandey
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
long non-coding RNAs
glioblastoma
blood-brain barrier
chemoresistance
therapeutics
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253121000895
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spelling doaj-876c3bae4c1047ea838313e25c42252f2021-06-05T06:08:24ZengElsevierMolecular Therapy: Nucleic Acids2162-25312021-06-0124728742LncRNAs associated with glioblastoma: From transcriptional noise to novel regulators with a promising role in therapeuticsBhupender Yadav0Sonali Pal1Yury Rubstov2Akul Goel3Manoj Garg4Marat Pavlyukov5Amit Kumar Pandey6Amity Institute of Biotechnology, Amity University Haryana, Panchgaon, Manesar, Haryana 122413, IndiaAmity Institute of Biotechnology, Amity University Haryana, Panchgaon, Manesar, Haryana 122413, IndiaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, GSP-7, Ulitsa Miklukho-Maklaya, 16/10, 117997 Moscow, Russian Federation; Faculty of Biology and Biotechnology, National Research University Higher School of Economics, Vavilova Street 7, 117312 Moscow, Russian FederationLa Canada High School, La Canada Flintridge, CA 91011, USAAmity Institute of Molecular Medicine and Stem Cell Research (AIMMSCR), Amity University, Uttar Pradesh, Sector 125, Noida 201313, IndiaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, GSP-7, Ulitsa Miklukho-Maklaya, 16/10, 117997 Moscow, Russian FederationAmity Institute of Biotechnology, Amity University Haryana, Panchgaon, Manesar, Haryana 122413, India; Corresponding author: Amit Kumar Pandey, Amity Institute of Biotechnology, Amity University Haryana, Panchgaon, Manesar, Haryana 122413, India.Glioblastoma multiforme (GBM) is the most widespread and aggressive subtype of glioma in adult patients. Numerous long non-coding RNAs (lncRNAs) are deregulated or differentially expressed in GBM. These lncRNAs possess unique regulatory functions in GBM cells, ranging from high invasion/migration to recurrence. This review outlines the present status of specific involvement of lncRNAs in GBM pathogenesis, with a focus on their association with key molecular and cellular regulatory mechanisms. Also, we highlighted the potential of different novel RNA-based strategies that may be beneficial for therapeutic purposes.http://www.sciencedirect.com/science/article/pii/S2162253121000895long non-coding RNAsglioblastomablood-brain barrierchemoresistancetherapeutics
collection DOAJ
language English
format Article
sources DOAJ
author Bhupender Yadav
Sonali Pal
Yury Rubstov
Akul Goel
Manoj Garg
Marat Pavlyukov
Amit Kumar Pandey
spellingShingle Bhupender Yadav
Sonali Pal
Yury Rubstov
Akul Goel
Manoj Garg
Marat Pavlyukov
Amit Kumar Pandey
LncRNAs associated with glioblastoma: From transcriptional noise to novel regulators with a promising role in therapeutics
Molecular Therapy: Nucleic Acids
long non-coding RNAs
glioblastoma
blood-brain barrier
chemoresistance
therapeutics
author_facet Bhupender Yadav
Sonali Pal
Yury Rubstov
Akul Goel
Manoj Garg
Marat Pavlyukov
Amit Kumar Pandey
author_sort Bhupender Yadav
title LncRNAs associated with glioblastoma: From transcriptional noise to novel regulators with a promising role in therapeutics
title_short LncRNAs associated with glioblastoma: From transcriptional noise to novel regulators with a promising role in therapeutics
title_full LncRNAs associated with glioblastoma: From transcriptional noise to novel regulators with a promising role in therapeutics
title_fullStr LncRNAs associated with glioblastoma: From transcriptional noise to novel regulators with a promising role in therapeutics
title_full_unstemmed LncRNAs associated with glioblastoma: From transcriptional noise to novel regulators with a promising role in therapeutics
title_sort lncrnas associated with glioblastoma: from transcriptional noise to novel regulators with a promising role in therapeutics
publisher Elsevier
series Molecular Therapy: Nucleic Acids
issn 2162-2531
publishDate 2021-06-01
description Glioblastoma multiforme (GBM) is the most widespread and aggressive subtype of glioma in adult patients. Numerous long non-coding RNAs (lncRNAs) are deregulated or differentially expressed in GBM. These lncRNAs possess unique regulatory functions in GBM cells, ranging from high invasion/migration to recurrence. This review outlines the present status of specific involvement of lncRNAs in GBM pathogenesis, with a focus on their association with key molecular and cellular regulatory mechanisms. Also, we highlighted the potential of different novel RNA-based strategies that may be beneficial for therapeutic purposes.
topic long non-coding RNAs
glioblastoma
blood-brain barrier
chemoresistance
therapeutics
url http://www.sciencedirect.com/science/article/pii/S2162253121000895
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