LncRNAs associated with glioblastoma: From transcriptional noise to novel regulators with a promising role in therapeutics

LncRNAs associated with glioblastoma: From transcriptional noise to novel regulators with a promising role in therapeutics

Glioblastoma multiforme (GBM) is the most widespread and aggressive subtype of glioma in adult patients. Numerous long non-coding RNAs (lncRNAs) are deregulated or differentially expressed in GBM. These lncRNAs possess unique regulatory functions in GBM cells, ranging from high invasion/migration to...

Full description

Bibliographic Details
Main Authors: Bhupender Yadav, Sonali Pal, Yury Rubstov, Akul Goel, Manoj Garg, Marat Pavlyukov, Amit Kumar Pandey
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
long non-coding RNAs
glioblastoma
blood-brain barrier
chemoresistance
therapeutics
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253121000895
Description
Summary:Glioblastoma multiforme (GBM) is the most widespread and aggressive subtype of glioma in adult patients. Numerous long non-coding RNAs (lncRNAs) are deregulated or differentially expressed in GBM. These lncRNAs possess unique regulatory functions in GBM cells, ranging from high invasion/migration to recurrence. This review outlines the present status of specific involvement of lncRNAs in GBM pathogenesis, with a focus on their association with key molecular and cellular regulatory mechanisms. Also, we highlighted the potential of different novel RNA-based strategies that may be beneficial for therapeutic purposes.
ISSN:2162-2531

Similar Items