Relationship of incision infection after colorectal cancer surgery with the body ' s nutritional status, immune function and inflammatory factors

• Main Authors: Hua-Jun Fu, Shao-Lin Zhang, Hui-Ying Chen, Chong Zhao
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2017-04-01
• Series: Journal of Hainan Medical University
• Subjects: Radical operation for colorectal cancer; Incision infection; Immune function; Inflammatory factors
• Online Access: http://www.hnykdxxb.com/PDF/201707/17.pdf

Objective: To study the relationship of incision infection after colorectal cancer surgery with the body's nutritional status, immune function and inflammatory factors. Methods: 146 patients who received radical operation for colorectal cancer in our hospital between June 2013 and December 2015 were selected and divided into infection group and non-infection group respectively according to the postoperative incision infection. 1 d before operation, the same day after operation and 3 d after operation, serum was collected respectively to detect nutritional indexes and inflammatory factors, and peripheral blood was collected to determine the levels of immune cells and erythrocyte immune molecules. Results: The same day after operation, serum Hb, TP, Alb, PA and Tf levels of both groups were not significantly different from those 1 d before operation, the peripheral blood CD3+CD4+, CD3+CD8+, CD16+CD56+, CD19+, CR1, CR3, CD58 and CD59 levels were significantly lower (P<0.05) than those 1 d before operation, and 1 d before operation as well as the same day after operation, serum hemoglobin (Hb), total protein (TP), albumin (Alb), prealbumin (PA) and transferrin (Tf) levels as well as peripheral blood CD3+CD4+, CD3+CD8+, CD16+CD56+, CD19+, CR1, CR3, CD58 and CD59 levels of infection group were significantly lower (P<0.05) than those of non-infection group; 3 d after operation, serum TNF-α, PCT, IL-1β, MCP-1 and hs-CRP levels of infection group were significantly higher (P<0.05) than those of non-infection group and negatively correlated with serum Hb, TP, Alb, PA and Tf levels as well as peripheral blood CD3+CD4+, CD3+CD8+, CD16+CD56+, CD19+, CR1, CR3, CD58 and CD59 levels. Conclusion: Perioperative poor nutritional status and immunosuppression can increase the risk of incision infection and are closely related to the degree of inflammation.