Increased hepatic mitochondrial FA oxidation reduces plasma and liver TG levels and is associated with regulation of UCPs and APOC-III in rats

Increased hepatic mitochondrial FA oxidation reduces plasma and liver TG levels and is associated with regulation of UCPs and APOC-III in rats

Hepatic mitochondrial function, APOC-III, and LPL are potential targets for triglyceride (TG)-lowering drugs. After 3 weeks of dietary treatment with the compound 2-(tridec-12-yn-1-ylthio)acetic acid (1-triple TTA), the hepatic mitochondrial FA oxidation increased more than 5-fold in male Wistar rat...

Full description

Bibliographic Details
Main Authors:	Carine Lindquist, Bodil Bjørndal, Christine Renate Rossmann, Deusdedit Tusubira, Asbjørn Svardal, Gro Vatne Røsland, Karl Johan Tronstad, Seth Hallström, Rolf Kristian Berge
Format:	Article
Language:	English
Published:	Elsevier 2017-07-01
Series:	Journal of Lipid Research
Subjects:	2-(tridec-12-yn-1-ylthio)acetic acid lipids lipoproteins metabolic syndrome mitochondria nonalcoholic fatty liver disease
Online Access:	http://www.sciencedirect.com/science/article/pii/S0022227520335872

Similar Items

Multi-Disciplinary Approaches to Intelligently Sharing Large-Volumes of Real-Time Sensor Data During Natural Disasters
by: Stuart E Middleton, et al.
Published: (2013-02-01)

A fatty acid analogue targeting mitochondria exerts a plasma triacylglycerol lowering effect in rats with impaired carnitine biosynthesis.
by: Carine Lindquist, et al.
Published: (2018-01-01)

Bronchoskopische Vermessung und dreidimensionale Darstellung der Trachea
by: Sugano, Yoshimi Teresa
Published: (2006)

Anti-Toxoplasma Activity of 2-(Naphthalene-2-γlthiol)-1H Indole
by: Qasem Asgari, et al.
Published: (2015-06-01)

An Ab Initio Study of Pressure-Induced Reversal of Elastically Stiff and Soft Directions in YN and ScN and Its Effect in Nanocomposites Containing These Nitrides
by: Martin Friák, et al.
Published: (2018-12-01)

ANTIMICROBIAL EFFECT OF OLIGOMERIC COPPER(II) DERIVATIVES OF BIS(PYRIMIDIN-2-YLTHIO)- AND BIS(4,6-DIMETHYLPYRIMIDIN-2-YLTHIO)ALKANES
by: Ricardo Soares Mota Silva, et al.
Published: (2016-03-01)

Clinical Value Of Apatinib As A Salvage Treatment In Patients With Chemo-Refractory Advanced Cervical Cancer
by: Su M, et al.
Published: (2019-11-01)

Characterization and evaluation of antimicrobial and cytotoxic effects of Streptomyces sp. HUST012 isolated from medicinal plant Dracaena cochinchinensis Lour.
by: Thi-Nhan eKhieu, et al.
Published: (2015-06-01)

Actoprotective action of sodium 2-(tetrazol[1,5-c]quinazolin-5-ylthio)acetate in acute hemic hypoxia
by: O. Yu. Toziuk
Published: (2017-02-01)

Immune-Mediated Antitumor Effect By VEGFR2 Selective Inhibitor For Gastric Cancer
by: Yang J, et al.
Published: (2019-11-01)

Synthesis and characterisation of organotin(IV) derivatives of ambidentate ligands containing nitrogen and sulphur donor atoms
by: Chagas Rafael César Russo, et al.
Published: (2011-12-01)

FORMATION OF THE JUNIOR SCHOOLCHELDREN ATTITUDE TO THE NATIONAL SONG FOLKLORE BY THE MEANS OF MULTIMEDIA TECHNOLOGIES
by: A. Vladimirovа
Published: (2014-06-01)

Potential of N-aryl(benzyl,heteryl)-2-(tetrazolo[1,5-c]quinazolin-5-ylthio)acetamides as anticancer and antimicrobial agents
by: Oleksii M. Antypenko, et al.
Published: (2016-11-01)

Comparative pharmacokinetic study of dosage forms with morpholinium 2-[5-(pyridin-4-yl)-1,2,4-triazol-3-ylthio] acetate
by: I. V. Bushueva, et al.
Published: (2014-12-01)

Associations between fatty acid oxidation, hepatic mitochondrial function, and plasma acylcarnitine levels in mice
by: Bodil Bjørndal, et al.
Published: (2018-01-01)

Isolierung, Kultivierung und magnetische Separation von Vorläuferzellen aus humanem respiratorischem Epithel
by: Wentges, Marek
Published: (2004)

Conclusion on the peer review of the pesticide risk assessment of the active substance Z‐13‐hexadecen‐11‐yn‐1‐yl acetate
by: European Food Safety Authority
Published: (2014-12-01)

Synthesis, spectral analysis and pharmacological study of N’-substituted-2-(5-((2,4-dimethylphenoxy)methyl)-1,3,4-oxadiazol-2-ylthio)acetohydrazides
by: Abbasi, M.A, et al.
Published: (2016)

2-(3,4-Dihydro-4-Oxothieno[2,3-d]pyrimidin-2-ylthio) Acetamides as a New Class of Falcipain-2 Inhibitors. 3. Design, Synthesis and Biological Evaluation
by: Hualiang Jiang, et al.
Published: (2009-02-01)

Crystal structure of 2-hydroxy-3-(prop-2-yn-1-yl)naphthalene-1,4-dione
by: Isidório Raquel Geralda, et al.
Published: (2018-09-01)

Colloidal synthesis of Culn0.75Ga0.25Se2 nanoparticles and their photovoltaic performance
by: Mubiayi Kalenga Pierre, et al.
Published: (2016-01-01)

Crystal structure of bis(prop-2-yn-1-yl) 5-nitroisophthalate
by: K. S. Ezhilarasi, et al.
Published: (2015-06-01)

Crystal structure of 4-(prop-2-yn-1-yloxy)benzonitrile
by: Mayu Kanagawa, et al.
Published: (2015-02-01)

Temporäre Harmonisierung des monotonalen Tinnitus mittels transponierter Musik ‒ Smetana-Phänomen
by: Tymnik, Gerd, et al.
Published: (2018)

Biochemical aspects of KB-28 compound on physically loaded study subjects
by: Toziuk Olena, et al.
Published: (2019-09-01)

A Phospholipid-Protein Complex from Antarctic Krill Reduced Plasma Homocysteine Levels and Increased Plasma Trimethylamine-N-Oxide (TMAO) and Carnitine Levels in Male Wistar Rats
by: Bodil Bjørndal, et al.
Published: (2015-09-01)

Die Aussagekraft der Umfelddiagnostik bezüglich der sekundären Prävention beim Hörsturz
by: Yasar, Halil Ibrahim
Published: (2001)

Synthesis and In-vitro Antitumor Activity of 1-[3-(Indol-1-yl)prop-1-yn-1-yl]phthalazines and Related Compounds
by: Angelika Plenk, et al.
Published: (2007-08-01)

Some aspects of synthesis of new 2-((5-furan-2-yl, 2-metylfuran-3-yl)-4-amino-1,2,4-triazole-3-ylthio)acetic acid esters
by: D. M. Danilchenko
Published: (2016-12-01)

Molekularzytogenetische Charakterisierung von Plattenepithelkarzinomen des Kopf-Hals-Bereiches
by: Bockmühl, Ulrike
Published: (1999)

Investigating the role of the APOC2, APOC3 and APOA5 genes in hypertriglyceridaemia
by: Wright, W. T.
Published: (2004)

Identification of an apoC-II variant (apoC-IIBethesda) in a kindred with apoC-II deficiency and type I hyperlipoproteinemia.
by: D L Sprecher, et al.
Published: (1988-03-01)

Short-Term Activation of Peroxisome Proliferator-Activated Receptors α and γ Induces Tissue-Specific Effects on Lipid Metabolism and Fatty Acid Composition in Male Wistar Rats
by: Elin Strand, et al.
Published: (2019-01-01)

Lipid, fatty acid, carnitine- and choline derivative profiles in rheumatoid arthritis outpatients with different degrees of periodontal inflammation
by: Kathrin Beyer, et al.
Published: (2021-03-01)

40 Years of the APOC Partnership.
by: Jean-Baptist Roungou, et al.
Published: (2015-05-01)

Plasma turnover of HDL apoC-I, apoC-III, and apoE in humans
by: Jeffrey S. Cohn, et al.
Published: (2003-10-01)

Ecology and Molecular Characterization of Neozygites tanajoae (Entomophthorales: Neozygitaceae) a fungal pathogen of the cassava green mite
by: Agboton, Vidjannagni Bonaventure
Published: (2009)

Anaesthesia Preoperative Clinic (APOC) Audit
by: Dass, Deshandra
Published: (2017)

Fish oil and the pan-PPAR agonist tetradecylthioacetic acid affect the amino acid and carnitine metabolism in rats.
by: Bodil Bjørndal, et al.
Published: (2013-01-01)

Severe hypertriglyceridemia in human APOC1 transgenic mice is caused by apoC-I-induced inhibition of LPL
by: Jimmy F.P. Berbée, et al.
Published: (2005-02-01)