Shielding and activation of a viral membrane fusion protein

Shielding and activation of a viral membrane fusion protein

Viral fusion proteins undergo extensive conformational changes during entry but intermediate conformations often remain unknown. Here, the authors show how Gn of Rift Valley fever virus fusion protein shields hydrophobic fusion loops of Gc and how these loops embed in the target membrane at acidic c...

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Main Authors: Steinar Halldorsson, Sai Li, Mengqiu Li, Karl Harlos, Thomas A. Bowden, Juha T. Huiskonen
Format: Article
Language:English
Published: Nature Publishing Group 2018-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-02789-2
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spelling doaj-875fd015c6954da8bc20cc2adff407bf2021-05-11T09:21:30ZengNature Publishing GroupNature Communications2041-17232018-01-01911910.1038/s41467-017-02789-2Shielding and activation of a viral membrane fusion proteinSteinar Halldorsson0Sai Li1Mengqiu Li2Karl Harlos3Thomas A. Bowden4Juha T. Huiskonen5Division of Structural Biology, Wellcome Centre for Human Genetics, University of OxfordDivision of Structural Biology, Wellcome Centre for Human Genetics, University of OxfordDivision of Structural Biology, Wellcome Centre for Human Genetics, University of OxfordDivision of Structural Biology, Wellcome Centre for Human Genetics, University of OxfordDivision of Structural Biology, Wellcome Centre for Human Genetics, University of OxfordDivision of Structural Biology, Wellcome Centre for Human Genetics, University of OxfordViral fusion proteins undergo extensive conformational changes during entry but intermediate conformations often remain unknown. Here, the authors show how Gn of Rift Valley fever virus fusion protein shields hydrophobic fusion loops of Gc and how these loops embed in the target membrane at acidic conditions.https://doi.org/10.1038/s41467-017-02789-2
collection DOAJ
language English
format Article
sources DOAJ
author Steinar Halldorsson
Sai Li
Mengqiu Li
Karl Harlos
Thomas A. Bowden
Juha T. Huiskonen
spellingShingle Steinar Halldorsson
Sai Li
Mengqiu Li
Karl Harlos
Thomas A. Bowden
Juha T. Huiskonen
Shielding and activation of a viral membrane fusion protein
Nature Communications
author_facet Steinar Halldorsson
Sai Li
Mengqiu Li
Karl Harlos
Thomas A. Bowden
Juha T. Huiskonen
author_sort Steinar Halldorsson
title Shielding and activation of a viral membrane fusion protein
title_short Shielding and activation of a viral membrane fusion protein
title_full Shielding and activation of a viral membrane fusion protein
title_fullStr Shielding and activation of a viral membrane fusion protein
title_full_unstemmed Shielding and activation of a viral membrane fusion protein
title_sort shielding and activation of a viral membrane fusion protein
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-01-01
description Viral fusion proteins undergo extensive conformational changes during entry but intermediate conformations often remain unknown. Here, the authors show how Gn of Rift Valley fever virus fusion protein shields hydrophobic fusion loops of Gc and how these loops embed in the target membrane at acidic conditions.
url https://doi.org/10.1038/s41467-017-02789-2
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AT saili shieldingandactivationofaviralmembranefusionprotein
AT mengqiuli shieldingandactivationofaviralmembranefusionprotein
AT karlharlos shieldingandactivationofaviralmembranefusionprotein
AT thomasabowden shieldingandactivationofaviralmembranefusionprotein
AT juhathuiskonen shieldingandactivationofaviralmembranefusionprotein
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