Infectious cell culture systems of hepatitis C virus and their application in drug development

To date, the infectious cell culture systems of hepatitis C virus (HCV) representative of genotypes 1-3 have been developed with the aid of adaptive mutations identified from JFH1-based chimera viruses or replicons. Nevertheless, JFH1 is still the unique clone capable of spontaneous replication in l...

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Main Author:	LI Yiping
Format:	Article
Language:	zho
Published:	Editorial Department of Journal of Clinical Hepatology 2015-11-01
Series:	Linchuang Gandanbing Zazhi
Online Access:	http://www.lcgdbzz.org/qk_content.asp?id=6938

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spelling	doaj-8751654e42d443798a9b4a2546be9ad52020-11-24T23:23:21ZzhoEditorial Department of Journal of Clinical HepatologyLinchuang Gandanbing Zazhi1001-52561001-52562015-11-0131111825183010.3969/j.issn.1001-5256.2015.11.014Infectious cell culture systems of hepatitis C virus and their application in drug developmentLI Yiping0Institute of Human Virology, Zhongshan School of Medicine, and Key Laboratory of Tropical Disease Control of Ministry of Education, Sun Yat-sen University, Guangzhou 510080, ChinaTo date, the infectious cell culture systems of hepatitis C virus (HCV) representative of genotypes 1-3 have been developed with the aid of adaptive mutations identified from JFH1-based chimera viruses or replicons. Nevertheless, JFH1 is still the unique clone capable of spontaneous replication in liver cell lines. It is an urgent need to develop a universal infectious cell culture system for any HCV clinical isolate. This article reviews the progress in HCV cell culture systems, existing infectious HCV clones, and permissive cell lines supporting HCV replication, as well as the application of HCV replication and infection model in drug development.http://www.lcgdbzz.org/qk_content.asp?id=6938
collection	DOAJ
language	zho
format	Article
sources	DOAJ
author	LI Yiping
spellingShingle	LI Yiping Infectious cell culture systems of hepatitis C virus and their application in drug development Linchuang Gandanbing Zazhi
author_facet	LI Yiping
author_sort	LI Yiping
title	Infectious cell culture systems of hepatitis C virus and their application in drug development
title_short	Infectious cell culture systems of hepatitis C virus and their application in drug development
title_full	Infectious cell culture systems of hepatitis C virus and their application in drug development
title_fullStr	Infectious cell culture systems of hepatitis C virus and their application in drug development
title_full_unstemmed	Infectious cell culture systems of hepatitis C virus and their application in drug development
title_sort	infectious cell culture systems of hepatitis c virus and their application in drug development
publisher	Editorial Department of Journal of Clinical Hepatology
series	Linchuang Gandanbing Zazhi
issn	1001-5256 1001-5256
publishDate	2015-11-01
description	To date, the infectious cell culture systems of hepatitis C virus (HCV) representative of genotypes 1-3 have been developed with the aid of adaptive mutations identified from JFH1-based chimera viruses or replicons. Nevertheless, JFH1 is still the unique clone capable of spontaneous replication in liver cell lines. It is an urgent need to develop a universal infectious cell culture system for any HCV clinical isolate. This article reviews the progress in HCV cell culture systems, existing infectious HCV clones, and permissive cell lines supporting HCV replication, as well as the application of HCV replication and infection model in drug development.
url	http://www.lcgdbzz.org/qk_content.asp?id=6938
work_keys_str_mv	AT liyiping infectiouscellculturesystemsofhepatitiscvirusandtheirapplicationindrugdevelopment
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Infectious cell culture systems of hepatitis C virus and their application in drug development

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