Antiretroviral Therapy – Changes of Basic Laboratory Parameters in Hiv-Infected Bulgarian Patients

HIV-1 infection keeps on being a global problem because of its pandemic character and the impossibility for eradication. The combined antiretroviral therapy (АRТ) remains the only treatment which has proven its effectiveness for maintaining the life of HIV positive patients. Because of long term (li...

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Main Author: Stojanova Yancheva Nina
Format: Article
Language:English
Published: Sciendo 2015-11-01
Series:Acta Medica Bulgarica
Subjects:
hiv
art
Online Access:https://doi.org/10.1515/amb-2015-0012
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spelling doaj-8743d924370d4eb880ef86b835fa66982021-09-06T19:39:48ZengSciendoActa Medica Bulgarica0324-17502015-11-0142251510.1515/amb-2015-0012amb-2015-0012Antiretroviral Therapy – Changes of Basic Laboratory Parameters in Hiv-Infected Bulgarian PatientsStojanova Yancheva Nina0Department for Patients with Acquired Immune Deficiency, Specialized Hospital for Active Treatment of Ifectious and Parasitic Diseases „Prof. Ivan Kirov“ - Sofia Department of Infectious Diseases, Parasitology and Tropical Medicine, Sofia Medical University-Ward for Patients with Acquired Immunodeficiency, Hospital "Prof. Ivan Kirov", 17 "Academic Ivan Geshov" Blvd. SofiaHIV-1 infection keeps on being a global problem because of its pandemic character and the impossibility for eradication. The combined antiretroviral therapy (АRТ) remains the only treatment which has proven its effectiveness for maintaining the life of HIV positive patients. Because of long term (life time) duration of this therapy, it is necessary to monitor patients for possible drug toxicity. The aim of our research is to evaluate the changes of basic laboratory examinations while conducting a long-term АRТ. We analyzed basic laboratory studies of 145 HIV-infected Bulgarian patients in the current research. The patients were separated into four groups according to their treatment regimen. They were on dispensary monitoring and were being treated in the Department for Patients with Acquired Immune Deficiency in the Specialized Hospital for Active Treatment of Infectious and Parasitic Diseases “Prof. Ivan Kirov” - Sofia. Our results showed that combined ART led to changes in blood count, alanin-aminotransferase (ALT), glucose and total cholesterol. Some of these changes are significant for some of the drugs administered. The current ART does not lead to severe toxicity and life-threatening conditions such as those which were observed in the first few years of ART introduction.https://doi.org/10.1515/amb-2015-0012hivartcombined antiretroviral therapylaboratory parameters
collection DOAJ
language English
format Article
sources DOAJ
author Stojanova Yancheva Nina
spellingShingle Stojanova Yancheva Nina
Antiretroviral Therapy – Changes of Basic Laboratory Parameters in Hiv-Infected Bulgarian Patients
Acta Medica Bulgarica
hiv
art
combined antiretroviral therapy
laboratory parameters
author_facet Stojanova Yancheva Nina
author_sort Stojanova Yancheva Nina
title Antiretroviral Therapy – Changes of Basic Laboratory Parameters in Hiv-Infected Bulgarian Patients
title_short Antiretroviral Therapy – Changes of Basic Laboratory Parameters in Hiv-Infected Bulgarian Patients
title_full Antiretroviral Therapy – Changes of Basic Laboratory Parameters in Hiv-Infected Bulgarian Patients
title_fullStr Antiretroviral Therapy – Changes of Basic Laboratory Parameters in Hiv-Infected Bulgarian Patients
title_full_unstemmed Antiretroviral Therapy – Changes of Basic Laboratory Parameters in Hiv-Infected Bulgarian Patients
title_sort antiretroviral therapy – changes of basic laboratory parameters in hiv-infected bulgarian patients
publisher Sciendo
series Acta Medica Bulgarica
issn 0324-1750
publishDate 2015-11-01
description HIV-1 infection keeps on being a global problem because of its pandemic character and the impossibility for eradication. The combined antiretroviral therapy (АRТ) remains the only treatment which has proven its effectiveness for maintaining the life of HIV positive patients. Because of long term (life time) duration of this therapy, it is necessary to monitor patients for possible drug toxicity. The aim of our research is to evaluate the changes of basic laboratory examinations while conducting a long-term АRТ. We analyzed basic laboratory studies of 145 HIV-infected Bulgarian patients in the current research. The patients were separated into four groups according to their treatment regimen. They were on dispensary monitoring and were being treated in the Department for Patients with Acquired Immune Deficiency in the Specialized Hospital for Active Treatment of Infectious and Parasitic Diseases “Prof. Ivan Kirov” - Sofia. Our results showed that combined ART led to changes in blood count, alanin-aminotransferase (ALT), glucose and total cholesterol. Some of these changes are significant for some of the drugs administered. The current ART does not lead to severe toxicity and life-threatening conditions such as those which were observed in the first few years of ART introduction.
topic hiv
art
combined antiretroviral therapy
laboratory parameters
url https://doi.org/10.1515/amb-2015-0012
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