Resuscitation with macromolecular superoxide dismutase/catalase mimetic polynitroxylated PEGylated hemoglobin offers neuroprotection in guinea pigs after traumatic brain injury combined with hemorrhage shock

Resuscitation with macromolecular superoxide dismutase/catalase mimetic polynitroxylated PEGylated hemoglobin offers neuroprotection in guinea pigs after traumatic brain injury combined with hemorrhage shock

Abstract Background Polynitroxylated PEGylated hemoglobin (PNPH, aka SanFlow) possesses superoxide dismutase/catalase mimetic activities that may directly protect the brain from oxidative stress. Stabilization of PNPH with bound carbon monoxide prevents methemoglobin formation during storage and per...

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Bibliographic Details
Main Authors: Soichiro Seno, Jun Wang, Suyi Cao, Manda Saraswati, Sharon Park, Jan Simoni, Li Ma, Bohdan Soltys, Carleton J. C. Hsia, Raymond C. Koehler, Courtney L. Robertson
Format: Article
Language:English
Published: BMC 2020-05-01
Series:BMC Neuroscience
Subjects:
Carbon monoxide
Controlled cortical impact
Guinea pig
Hemoglobin-based oxygen carrier
Hippocampus
Neuroprotection
Online Access:http://link.springer.com/article/10.1186/s12868-020-00571-7

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