Steroid hormones sulfatase inactivation extends lifespan and ameliorates age-related diseases
Sul-2 is a steroid sulfatase in c.elegans. Here the authors show that, in the absence of sul-2 enzymatic activity, worm lifespan is increased, and that chemical inhibition ameliorates symptoms of neurodegenerative disorders in worms and mice.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2021-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-20269-y |
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doaj-873769f1ad43491084d967f67bef724d2021-01-10T12:18:09ZengNature Publishing GroupNature Communications2041-17232021-01-0112111210.1038/s41467-020-20269-ySteroid hormones sulfatase inactivation extends lifespan and ameliorates age-related diseasesMercedes M. Pérez-Jiménez0José M. Monje-Moreno1Ana María Brokate-Llanos2Mónica Venegas-Calerón3Alicia Sánchez-García4Paula Sansigre5Amador Valladares6Sara Esteban-García7Irene Suárez-Pereira8Javier Vitorica9José Julián Ríos10Marta Artal-Sanz11Ángel M. Carrión12Manuel J. Muñoz13Centro Andaluz de Biología del Desarrollo (CABD)—Universidad Pablo de Olavide (UPO), Departamento de Biología Molecular e Ingeniería Bioquímica, UPO/ CSIC/JACentro Andaluz de Biología del Desarrollo (CABD)—Universidad Pablo de Olavide (UPO), Departamento de Biología Molecular e Ingeniería Bioquímica, UPO/ CSIC/JACentro Andaluz de Biología del Desarrollo (CABD)—Universidad Pablo de Olavide (UPO), Departamento de Biología Molecular e Ingeniería Bioquímica, UPO/ CSIC/JAInstituto de la Grasa (CSIC), Campus Universitario Pablo de Olavide (UPO)Instituto de la Grasa (CSIC), Campus Universitario Pablo de Olavide (UPO)Centro Andaluz de Biología del Desarrollo (CABD)—Universidad Pablo de Olavide (UPO), Departamento de Biología Molecular e Ingeniería Bioquímica, UPO/ CSIC/JACentro Andaluz de Biología del Desarrollo (CABD)—Universidad Pablo de Olavide (UPO), Departamento de Biología Molecular e Ingeniería Bioquímica, UPO/ CSIC/JADepartamento de Fisiología, Anatomía y Biología Celular, Universidad Pablo de Olavide (UPO)Departamento de Fisiología, Anatomía y Biología Celular, Universidad Pablo de Olavide (UPO)Departamento de Bioquímica y Biología Molecular, Facultad de Farmacia, Universidad de SevillaInstituto de la Grasa (CSIC), Campus Universitario Pablo de Olavide (UPO)Centro Andaluz de Biología del Desarrollo (CABD)—Universidad Pablo de Olavide (UPO), Departamento de Biología Molecular e Ingeniería Bioquímica, UPO/ CSIC/JADepartamento de Fisiología, Anatomía y Biología Celular, Universidad Pablo de Olavide (UPO)Centro Andaluz de Biología del Desarrollo (CABD)—Universidad Pablo de Olavide (UPO), Departamento de Biología Molecular e Ingeniería Bioquímica, UPO/ CSIC/JASul-2 is a steroid sulfatase in c.elegans. Here the authors show that, in the absence of sul-2 enzymatic activity, worm lifespan is increased, and that chemical inhibition ameliorates symptoms of neurodegenerative disorders in worms and mice.https://doi.org/10.1038/s41467-020-20269-y |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Mercedes M. Pérez-Jiménez José M. Monje-Moreno Ana María Brokate-Llanos Mónica Venegas-Calerón Alicia Sánchez-García Paula Sansigre Amador Valladares Sara Esteban-García Irene Suárez-Pereira Javier Vitorica José Julián Ríos Marta Artal-Sanz Ángel M. Carrión Manuel J. Muñoz |
| spellingShingle |
Mercedes M. Pérez-Jiménez José M. Monje-Moreno Ana María Brokate-Llanos Mónica Venegas-Calerón Alicia Sánchez-García Paula Sansigre Amador Valladares Sara Esteban-García Irene Suárez-Pereira Javier Vitorica José Julián Ríos Marta Artal-Sanz Ángel M. Carrión Manuel J. Muñoz Steroid hormones sulfatase inactivation extends lifespan and ameliorates age-related diseases Nature Communications |
| author_facet |
Mercedes M. Pérez-Jiménez José M. Monje-Moreno Ana María Brokate-Llanos Mónica Venegas-Calerón Alicia Sánchez-García Paula Sansigre Amador Valladares Sara Esteban-García Irene Suárez-Pereira Javier Vitorica José Julián Ríos Marta Artal-Sanz Ángel M. Carrión Manuel J. Muñoz |
| author_sort |
Mercedes M. Pérez-Jiménez |
| title |
Steroid hormones sulfatase inactivation extends lifespan and ameliorates age-related diseases |
| title_short |
Steroid hormones sulfatase inactivation extends lifespan and ameliorates age-related diseases |
| title_full |
Steroid hormones sulfatase inactivation extends lifespan and ameliorates age-related diseases |
| title_fullStr |
Steroid hormones sulfatase inactivation extends lifespan and ameliorates age-related diseases |
| title_full_unstemmed |
Steroid hormones sulfatase inactivation extends lifespan and ameliorates age-related diseases |
| title_sort |
steroid hormones sulfatase inactivation extends lifespan and ameliorates age-related diseases |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2021-01-01 |
| description |
Sul-2 is a steroid sulfatase in c.elegans. Here the authors show that, in the absence of sul-2 enzymatic activity, worm lifespan is increased, and that chemical inhibition ameliorates symptoms of neurodegenerative disorders in worms and mice. |
| url |
https://doi.org/10.1038/s41467-020-20269-y |
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