Topoisomerase I as a Biomarker: Detection of Activity at the Single Molecule Level

Topoisomerase I as a Biomarker: Detection of Activity at the Single Molecule Level

Human topoisomerase I (hTopI) is an essential cellular enzyme. The enzyme is often upregulated in cancer cells, and it is a target for chemotherapeutic drugs of the camptothecin (CPT) family. Response to CPT-based treatment is dependent on hTopI activity, and reduction in activity, and mutations in...

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Bibliographic Details
Main Authors: Joanna Proszek, Amit Roy, Ann-Katrine Jakobsen, Rikke Frøhlich, Birgitta R. Knudsen, Magnus Stougaard
Format: Article
Language:English
Published: MDPI AG 2014-01-01
Series:Sensors
Subjects:
Topoisomerase-I
camptothecin
enzyme activity
biosensor
tyrosyl-DNA phosphodiesterase 1
single molecule
drug response
cancer
Online Access:http://www.mdpi.com/1424-8220/14/1/1195

Internet

http://www.mdpi.com/1424-8220/14/1/1195

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