Hydrogen Sulfide Plays an Important Role in Diabetic Cardiomyopathy

• Main Authors: Shizhen Zhao, Xiaotian Li, Xinping Li, Xiaoyun Wei, Honggang Wang
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2021-02-01
• Series: Frontiers in Cell and Developmental Biology
• Subjects: hydrogen sulfide; diabetic; cardiovascular diseases; diabetic cardiomyopathy; diabetic vascular diseases
• Online Access: https://www.frontiersin.org/articles/10.3389/fcell.2021.627336/full

Diabetic cardiomyopathy is an important complication of diabetes mellitus and the main cause of diabetes death. Diabetic cardiomyopathy is related with many factors, such as hyperglycemia, lipid accumulation, oxidative stress, myocarditis, and apoptosis. Hydrogen sulfide (H2S) is a newly discovered signal molecule, which plays an important role in many physiological and pathological processes. Recent studies have shown that H2S is involved in improving diabetic cardiomyopathy, but its mechanism has not been fully elucidated. This review summarizes the research on the roles and mechanisms of H2S in diabetic cardiomyopathy in recent years to provide the basis for in-depth research in the future.