SETD2-Dependent Histone H3K36 Trimethylation Is Required for Homologous Recombination Repair and Genome Stability

SETD2-Dependent Histone H3K36 Trimethylation Is Required for Homologous Recombination Repair and Genome Stability

Modulating chromatin through histone methylation orchestrates numerous cellular processes. SETD2-dependent trimethylation of histone H3K36 is associated with active transcription. Here, we define a role for H3K36 trimethylation in homologous recombination (HR) repair in human cells. We find that dep...

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Bibliographic Details
Main Authors: Sophia X. Pfister, Sara Ahrabi, Lykourgos-Panagiotis Zalmas, Sovan Sarkar, François Aymard, Csanád Z. Bachrati, Thomas Helleday, Gaëlle Legube, Nicholas B. La Thangue, Andrew C.G. Porter, Timothy C. Humphrey
Format: Article
Language:English
Published: Elsevier 2014-06-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471400401X

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http://www.sciencedirect.com/science/article/pii/S221112471400401X

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