POU2F2‐IL‐31 Autoregulatory Circuit Converts Hepatocytes into the Origin Cells of Hepatocellular Carcinoma

POU2F2‐IL‐31 Autoregulatory Circuit Converts Hepatocytes into the Origin Cells of Hepatocellular Carcinoma

Abstract Hepatocellular carcinoma (HCC) originates from fully differentiated hepatocytes, but the decisive events for converting hepatocytes to the cells of origin for HCC are still unclear. Liver cancer stem cells (LCSCs) cause HCC but are not bona fide cells of origin. Here, the expressions of POU...

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Bibliographic Details
Main Authors: Chunwang Yuan, Lijun Pang, Wenjing Wang, Yabo Ouyang, Xianghua Guo, Kai Liu
Format: Article
Language:English
Published: Wiley 2021-07-01
Series:Advanced Science
Subjects:
hepatocellular carcinoma
IL‐31
liver cancer stem cells
origin cells
p53
POU2F2
Online Access:https://doi.org/10.1002/advs.202004683

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