A robust synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin

A robust synthesis of 7,8-didemethyl-8-hydroxy-5-deazariboflavin

The biosynthetic precursor of redox cofactor F420, 7,8-didemethyl-8-hydroxy-5-deazariboflavin, was prepared in four steps from 6-chlorouracil, 2-chloro-4-hydroxybenzaldehyde and bis-isopropylidene protected D-ribose. The latter aldehyde was transformed to the corresponding protected ribitylamine via...

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Bibliographic Details
Main Authors: Matthias Bender, Henrik Mouritsen, Jens Christoffers
Format: Article
Language:English
Published: Beilstein-Institut 2016-05-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
carbohydrates
heterocyclic compounds
protective groups
riboflavin derivatives
ribose derivatives
Online Access:https://doi.org/10.3762/bjoc.12.89

Internet

https://doi.org/10.3762/bjoc.12.89

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