HMGB1 Protects the Heart Against Ischemia–Reperfusion Injury via PI3K/AkT Pathway-Mediated Upregulation of VEGF Expression

HMGB1 Protects the Heart Against Ischemia–Reperfusion Injury via PI3K/AkT Pathway-Mediated Upregulation of VEGF Expression

Delivery of exogenous high mobility group box 1 (HMGB1) may exert a beneficial effect on myocardial ischemia–reperfusion (I/R) injury. Since the expression of vascular endothelial growth factor (VEGF) and phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) in the myocardium mediates the cardio...

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Bibliographic Details
Main Authors: Yan-Hong Zhou, Qian-Feng Han, Lei Gao, Ying Sun, Zhan-Wei Tang, Meng Wang, Wei Wang, Heng-Chen Yao
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Physiology
Subjects:
myocardial ischemia–reperfusion injury
high mobility group box 1
vascular endothelial growth factor
PI3K/Akt pathway
acute myocardial infarction
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.01595/full

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