A New Alternative Synthesis of Salicylaldazine via Microwave Irradiation Method

A New Alternative Synthesis of Salicylaldazine via Microwave Irradiation Method

Two diazine Schiff base ligands, HLa and HLb, derived from thiocarbohydrazide and salicylaldehyde derivatives were synthesized using the microwave-assisted synthesis approach. The confirmation of both ligands was elucidated through physiochemical and spectroscopy techniques as well as single X-ray c...

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Main Authors: Karimah Kassim, Muhamad Azwan Hamali, Bohari Yamin
Format: Article
Language:English
Published: Hindawi Limited 2019-01-01
Series:Journal of Chemistry
Online Access:http://dx.doi.org/10.1155/2019/9546373
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spelling doaj-870759c0c416448884e4f8605baa5cdb2020-11-25T01:36:56ZengHindawi LimitedJournal of Chemistry2090-90632090-90712019-01-01201910.1155/2019/95463739546373A New Alternative Synthesis of Salicylaldazine via Microwave Irradiation MethodKarimah Kassim0Muhamad Azwan Hamali1Bohari Yamin2Institute of Science, Universiti Teknologi MARA, 40450 Shah Alam, MalaysiaFaculty of Applied Sciences, Universiti Teknologi MARA, 40450 Shah Alam, MalaysiaFaculty of Science and Technology, Universiti Sains Islam Malaysia, 71800 Nilai, MalaysiaTwo diazine Schiff base ligands, HLa and HLb, derived from thiocarbohydrazide and salicylaldehyde derivatives were synthesized using the microwave-assisted synthesis approach. The confirmation of both ligands was elucidated through physiochemical and spectroscopy techniques as well as single X-ray crystallography diffraction. The analyses showed that the ligands synthesized were formed as azine instead of thiocarbohydrazone based on the missing thione, C=S moiety, throughout FTIR and NMR spectrascopic data. This finding was further concluded by X-ray crystal analysis. The biological properties of these ligands were screened using the disc diffusion method. The result shows that HLb shows significant inhibition towards all of the bacteria tested.http://dx.doi.org/10.1155/2019/9546373
collection DOAJ
language English
format Article
sources DOAJ
author Karimah Kassim
Muhamad Azwan Hamali
Bohari Yamin
spellingShingle Karimah Kassim
Muhamad Azwan Hamali
Bohari Yamin
A New Alternative Synthesis of Salicylaldazine via Microwave Irradiation Method
Journal of Chemistry
author_facet Karimah Kassim
Muhamad Azwan Hamali
Bohari Yamin
author_sort Karimah Kassim
title A New Alternative Synthesis of Salicylaldazine via Microwave Irradiation Method
title_short A New Alternative Synthesis of Salicylaldazine via Microwave Irradiation Method
title_full A New Alternative Synthesis of Salicylaldazine via Microwave Irradiation Method
title_fullStr A New Alternative Synthesis of Salicylaldazine via Microwave Irradiation Method
title_full_unstemmed A New Alternative Synthesis of Salicylaldazine via Microwave Irradiation Method
title_sort new alternative synthesis of salicylaldazine via microwave irradiation method
publisher Hindawi Limited
series Journal of Chemistry
issn 2090-9063
2090-9071
publishDate 2019-01-01
description Two diazine Schiff base ligands, HLa and HLb, derived from thiocarbohydrazide and salicylaldehyde derivatives were synthesized using the microwave-assisted synthesis approach. The confirmation of both ligands was elucidated through physiochemical and spectroscopy techniques as well as single X-ray crystallography diffraction. The analyses showed that the ligands synthesized were formed as azine instead of thiocarbohydrazone based on the missing thione, C=S moiety, throughout FTIR and NMR spectrascopic data. This finding was further concluded by X-ray crystal analysis. The biological properties of these ligands were screened using the disc diffusion method. The result shows that HLb shows significant inhibition towards all of the bacteria tested.
url http://dx.doi.org/10.1155/2019/9546373
work_keys_str_mv AT karimahkassim anewalternativesynthesisofsalicylaldazineviamicrowaveirradiationmethod
AT muhamadazwanhamali anewalternativesynthesisofsalicylaldazineviamicrowaveirradiationmethod
AT bohariyamin anewalternativesynthesisofsalicylaldazineviamicrowaveirradiationmethod
AT karimahkassim newalternativesynthesisofsalicylaldazineviamicrowaveirradiationmethod
AT muhamadazwanhamali newalternativesynthesisofsalicylaldazineviamicrowaveirradiationmethod
AT bohariyamin newalternativesynthesisofsalicylaldazineviamicrowaveirradiationmethod
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