Source and Impact of the EGF Family of Ligands on Intestinal Stem Cells

Source and Impact of the EGF Family of Ligands on Intestinal Stem Cells

Epidermal Growth Factor (EGF) has long been known for its role in promoting proliferation of intestinal epithelial cells. EGF is produced by epithelial niche cells at the base of crypts in vivo and is routinely added to the culture medium to support the growth of intestinal organoids ex vivo. The re...

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Bibliographic Details
Main Authors: Helen E. Abud, Wing Hei Chan, Thierry Jardé
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Epidermal Growth Factor
neuregulin 1
intestinal stem cells
signaling
niche
ErbB
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.685665/full

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