Ethyl 3-(4-fluorophenyl)-6-methyl-4-oxo-2-(1-cyclohexylamino)-3,4-dihydrofuro[2,3-d]pyrimidine-5-carboxylate

In the crystal structure of the title compound, C22H24FN3O4, the two fused rings of furo[2,3-d]pyrimidine form a dihedral angle of 0.88 (13)°. The attached benzene ring is twisted with respect to the heterocyclic pyrimidinone ring, making a dihedral angle of 75.07 (12)&a...

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Main Authors:	Yong Sun, Guo-Ping Zeng, Yang-Gen Hu
Format:	Article
Language:	English
Published:	International Union of Crystallography 2008-01-01
Series:	Acta Crystallographica Section E
Online Access:	http://scripts.iucr.org/cgi-bin/paper?S1600536807066780

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record_format	Article
spelling	doaj-86f8c709503a4b55bf5279f2fcb6ede02020-11-25T02:30:48ZengInternational Union of CrystallographyActa Crystallographica Section E1600-53682008-01-01641o311o31210.1107/S1600536807066780Ethyl 3-(4-fluorophenyl)-6-methyl-4-oxo-2-(1-cyclohexylamino)-3,4-dihydrofuro[2,3-d]pyrimidine-5-carboxylateYong SunGuo-Ping ZengYang-Gen HuIn the crystal structure of the title compound, C22H24FN3O4, the two fused rings of furo[2,3-d]pyrimidine form a dihedral angle of 0.88 (13)°. The attached benzene ring is twisted with respect to the heterocyclic pyrimidinone ring, making a dihedral angle of 75.07 (12)°. The cyclohexyl ring shows a distorted chair conformation. The molecular structure is stabilized by intramolecular C—H...O and C—H...N hydrogen-bonding interactions. The crystal packing is mainly stabilized by C—H...π hydrogen-bond interactions. Further stability is provided by C—F...π and C—O...π stacking interactions.http://scripts.iucr.org/cgi-bin/paper?S1600536807066780
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yong Sun Guo-Ping Zeng Yang-Gen Hu
spellingShingle	Yong Sun Guo-Ping Zeng Yang-Gen Hu Ethyl 3-(4-fluorophenyl)-6-methyl-4-oxo-2-(1-cyclohexylamino)-3,4-dihydrofuro[2,3-d]pyrimidine-5-carboxylate Acta Crystallographica Section E
author_facet	Yong Sun Guo-Ping Zeng Yang-Gen Hu
author_sort	Yong Sun
title	Ethyl 3-(4-fluorophenyl)-6-methyl-4-oxo-2-(1-cyclohexylamino)-3,4-dihydrofuro[2,3-d]pyrimidine-5-carboxylate
title_short	Ethyl 3-(4-fluorophenyl)-6-methyl-4-oxo-2-(1-cyclohexylamino)-3,4-dihydrofuro[2,3-d]pyrimidine-5-carboxylate
title_full	Ethyl 3-(4-fluorophenyl)-6-methyl-4-oxo-2-(1-cyclohexylamino)-3,4-dihydrofuro[2,3-d]pyrimidine-5-carboxylate
title_fullStr	Ethyl 3-(4-fluorophenyl)-6-methyl-4-oxo-2-(1-cyclohexylamino)-3,4-dihydrofuro[2,3-d]pyrimidine-5-carboxylate
title_full_unstemmed	Ethyl 3-(4-fluorophenyl)-6-methyl-4-oxo-2-(1-cyclohexylamino)-3,4-dihydrofuro[2,3-d]pyrimidine-5-carboxylate
title_sort	ethyl 3-(4-fluorophenyl)-6-methyl-4-oxo-2-(1-cyclohexylamino)-3,4-dihydrofuro[2,3-d]pyrimidine-5-carboxylate
publisher	International Union of Crystallography
series	Acta Crystallographica Section E
issn	1600-5368
publishDate	2008-01-01
description	In the crystal structure of the title compound, C22H24FN3O4, the two fused rings of furo[2,3-d]pyrimidine form a dihedral angle of 0.88 (13)°. The attached benzene ring is twisted with respect to the heterocyclic pyrimidinone ring, making a dihedral angle of 75.07 (12)°. The cyclohexyl ring shows a distorted chair conformation. The molecular structure is stabilized by intramolecular C—H...O and C—H...N hydrogen-bonding interactions. The crystal packing is mainly stabilized by C—H...π hydrogen-bond interactions. Further stability is provided by C—F...π and C—O...π stacking interactions.
url	http://scripts.iucr.org/cgi-bin/paper?S1600536807066780
work_keys_str_mv	AT yongsun ethyl34fluorophenyl6methyl4oxo21cyclohexylamino34dihydrofuro23dpyrimidine5carboxylate AT guopingzeng ethyl34fluorophenyl6methyl4oxo21cyclohexylamino34dihydrofuro23dpyrimidine5carboxylate AT yanggenhu ethyl34fluorophenyl6methyl4oxo21cyclohexylamino34dihydrofuro23dpyrimidine5carboxylate
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Ethyl 3-(4-fluorophenyl)-6-methyl-4-oxo-2-(1-cyclohexylamino)-3,4-dihydrofuro[2,3-d]pyrimidine-5-carboxylate

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