Apigenin, by activating p53 and inhibiting STAT3, modulates the balance between pro-apoptotic and pro-survival pathways to induce PEL cell death

Apigenin, by activating p53 and inhibiting STAT3, modulates the balance between pro-apoptotic and pro-survival pathways to induce PEL cell death

Abstract Background Apigenin is a flavonoid widely distributed in plant kingdom that exerts cytotoxic effects against a variety of solid and haematological cancers. In this study, we investigated the effect of apigenin against primary effusion lymphoma (PEL), a KSHV-associated B cell lymphoma charac...

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Bibliographic Details
Main Authors: Marisa Granato, Maria Saveria Gilardini Montani, Roberta Santarelli, Gabriella D’Orazi, Alberto Faggioni, Mara Cirone
Format: Article
Language:English
Published: BMC 2017-11-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Apigenin
Apoptosis
Autophagy
KSHV
p53
PEL
Online Access:http://link.springer.com/article/10.1186/s13046-017-0632-z

Internet

http://link.springer.com/article/10.1186/s13046-017-0632-z

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