New Developments in Peritoneal Fibroblast Biology: Implications for Inflammation and Fibrosis in Peritoneal Dialysis

New Developments in Peritoneal Fibroblast Biology: Implications for Inflammation and Fibrosis in Peritoneal Dialysis

Uraemia and long-term peritoneal dialysis (PD) can lead to fibrotic thickening of the peritoneal membrane, which may limit its dialytic function. Peritoneal fibrosis is associated with the appearance of myofibroblasts and expansion of extracellular matrix. The extent of contribution of resident peri...

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Main Authors: Janusz Witowski, Edyta Kawka, Andras Rudolf, Achim Jörres
Format: Article
Language:English
Published: Hindawi Limited 2015-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2015/134708
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spelling doaj-86ef349e7bc34a58bb0731b8b59e2d462020-11-24T23:17:49ZengHindawi LimitedBioMed Research International2314-61332314-61412015-01-01201510.1155/2015/134708134708New Developments in Peritoneal Fibroblast Biology: Implications for Inflammation and Fibrosis in Peritoneal DialysisJanusz Witowski0Edyta Kawka1Andras Rudolf2Achim Jörres3Department of Pathophysiology, Poznan University of Medical Sciences, Medical Biology Centre, Rokietnicka 8, 60-806 Poznan, PolandDepartment of Pathophysiology, Poznan University of Medical Sciences, Medical Biology Centre, Rokietnicka 8, 60-806 Poznan, PolandDepartment of Pathophysiology, Poznan University of Medical Sciences, Medical Biology Centre, Rokietnicka 8, 60-806 Poznan, PolandDepartment of Nephrology and Medical Intensive Care, Charité-Universitätsmedizin Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353 Berlin, GermanyUraemia and long-term peritoneal dialysis (PD) can lead to fibrotic thickening of the peritoneal membrane, which may limit its dialytic function. Peritoneal fibrosis is associated with the appearance of myofibroblasts and expansion of extracellular matrix. The extent of contribution of resident peritoneal fibroblasts to these changes is a matter of debate. Recent studies point to a significant heterogeneity and complexity of the peritoneal fibroblast population. Here, we review recent developments in peritoneal fibroblast biology and summarize the current knowledge on the involvement of peritoneal fibroblasts in peritoneal inflammation and fibrosis.http://dx.doi.org/10.1155/2015/134708
collection DOAJ
language English
format Article
sources DOAJ
author Janusz Witowski
Edyta Kawka
Andras Rudolf
Achim Jörres
spellingShingle Janusz Witowski
Edyta Kawka
Andras Rudolf
Achim Jörres
New Developments in Peritoneal Fibroblast Biology: Implications for Inflammation and Fibrosis in Peritoneal Dialysis
BioMed Research International
author_facet Janusz Witowski
Edyta Kawka
Andras Rudolf
Achim Jörres
author_sort Janusz Witowski
title New Developments in Peritoneal Fibroblast Biology: Implications for Inflammation and Fibrosis in Peritoneal Dialysis
title_short New Developments in Peritoneal Fibroblast Biology: Implications for Inflammation and Fibrosis in Peritoneal Dialysis
title_full New Developments in Peritoneal Fibroblast Biology: Implications for Inflammation and Fibrosis in Peritoneal Dialysis
title_fullStr New Developments in Peritoneal Fibroblast Biology: Implications for Inflammation and Fibrosis in Peritoneal Dialysis
title_full_unstemmed New Developments in Peritoneal Fibroblast Biology: Implications for Inflammation and Fibrosis in Peritoneal Dialysis
title_sort new developments in peritoneal fibroblast biology: implications for inflammation and fibrosis in peritoneal dialysis
publisher Hindawi Limited
series BioMed Research International
issn 2314-6133
2314-6141
publishDate 2015-01-01
description Uraemia and long-term peritoneal dialysis (PD) can lead to fibrotic thickening of the peritoneal membrane, which may limit its dialytic function. Peritoneal fibrosis is associated with the appearance of myofibroblasts and expansion of extracellular matrix. The extent of contribution of resident peritoneal fibroblasts to these changes is a matter of debate. Recent studies point to a significant heterogeneity and complexity of the peritoneal fibroblast population. Here, we review recent developments in peritoneal fibroblast biology and summarize the current knowledge on the involvement of peritoneal fibroblasts in peritoneal inflammation and fibrosis.
url http://dx.doi.org/10.1155/2015/134708
work_keys_str_mv AT januszwitowski newdevelopmentsinperitonealfibroblastbiologyimplicationsforinflammationandfibrosisinperitonealdialysis
AT edytakawka newdevelopmentsinperitonealfibroblastbiologyimplicationsforinflammationandfibrosisinperitonealdialysis
AT andrasrudolf newdevelopmentsinperitonealfibroblastbiologyimplicationsforinflammationandfibrosisinperitonealdialysis
AT achimjorres newdevelopmentsinperitonealfibroblastbiologyimplicationsforinflammationandfibrosisinperitonealdialysis
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