Darolutamide antagonizes androgen signaling by blocking enhancer and super‐enhancer activation

Prostate cancer (PCa) is one of the most frequent tumor types in the male Western population. Early‐stage PCa and late‐stage PCa are dependent on androgen signaling, and inhibitors of the androgen receptor (AR) axis represent the standard therapy. Here, we studied in detail the global impact of daro...

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Bibliographic Details
Main Authors: Simon J. Baumgart, Ekaterina Nevedomskaya, Ralf Lesche, Richard Newman, Dominik Mumberg, Bernard Haendler
Format: Article
Language:English
Published: Wiley 2020-09-01
Series:Molecular Oncology
Subjects:
Online Access:https://doi.org/10.1002/1878-0261.12693