Triclosan Enhances the Clearing of Pathogenic Intracellular Salmonella or Candida albicans but Disturbs the Intestinal Microbiota through mTOR-Independent Autophagy

Triclosan Enhances the Clearing of Pathogenic Intracellular Salmonella or Candida albicans but Disturbs the Intestinal Microbiota through mTOR-Independent Autophagy

Triclosan (TCS) is a broad-spectrum antimicrobial agent, whose well-known antibacterial mechanism is inhibiting lipid synthesis. Autophagy, an innate immune response, is an intracellular process that delivers the cargo including pathogens to lysosomes for degradation. In this study, we first demonst...

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Bibliographic Details
Main Authors: Chao Wang, Zhongyang Yu, Xiaochen Shi, Xudong Tang, Yang Wang, Xueyan Wang, Yanan An, Shulin Li, Yan Li, Xuefei Wang, Wenjing Luan, Zhaobin Chen, Mingyuan Liu, Lu Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
triclosan
autophagy
mTOR-independent
macrophage
antimicrobial
Online Access:http://journal.frontiersin.org/article/10.3389/fcimb.2018.00049/full

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