Three-dimensional quantitative structure activity relationship (QSAR) of cytotoxic active 3,5-diaryl-4,5-dihydropyrazole analogs: a comparative molecular field analysis (CoMFA) revisited study

Three-dimensional quantitative structure activity relationship (QSAR) of cytotoxic active 3,5-diaryl-4,5-dihydropyrazole analogs: a comparative molecular field analysis (CoMFA) revisited study

<p>Abstract</p> <p>In vitro antitumor evaluation of the synthesized 46 compounds of 3,5-diaryl-4,5-dihydropyrazoles against EAC cell lines and 3D QSAR study using pharmacophore and Comparative Molecular Field Analysis <b>(</b>CoMFA) methods were described. CoMFA derived...

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Bibliographic Details
Main Authors: Hamad Elgazwy Abdel-Sattar S, Soliman DaliaH S, Atta-Allah Saad R, Ibrahim Diaa A
Format: Article
Language:English
Published: BMC 2012-05-01
Series:Chemistry Central Journal
Subjects:
3,5-diaryl-4,5-dihydropyrazole-1-carbothioamide
1-(3,5-diaryl-4,5-dihydropyrazol-1-yl)ethanethione
Antitumor
QSAR
CoMFA
Online Access:http://journal.chemistrycentral.com/content/6/1/50

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