Algebraic distribution of segmental duplication lengths in whole-genome sequence self-alignments.

Algebraic distribution of segmental duplication lengths in whole-genome sequence self-alignments.

Distributions of duplicated sequences from genome self-alignment are characterized, including forward and backward alignments in bacteria and eukaryotes. A Markovian process without auto-correlation should generate an exponential distribution expected from local effects of point mutation and selecti...

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Main Authors: Kun Gao, Jonathan Miller
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3136455?pdf=render
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spelling doaj-86d5043433ab4cf6af5ef55b7f1f89d62020-11-24T21:26:37ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-01-0167e1846410.1371/journal.pone.0018464Algebraic distribution of segmental duplication lengths in whole-genome sequence self-alignments.Kun GaoJonathan MillerDistributions of duplicated sequences from genome self-alignment are characterized, including forward and backward alignments in bacteria and eukaryotes. A Markovian process without auto-correlation should generate an exponential distribution expected from local effects of point mutation and selection on localised function; however, the observed distributions show substantial deviation from exponential form--they are roughly algebraic instead--suggesting a novel kind of long-distance correlation that must be non-local in origin.http://europepmc.org/articles/PMC3136455?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Kun Gao
Jonathan Miller
spellingShingle Kun Gao
Jonathan Miller
Algebraic distribution of segmental duplication lengths in whole-genome sequence self-alignments.
PLoS ONE
author_facet Kun Gao
Jonathan Miller
author_sort Kun Gao
title Algebraic distribution of segmental duplication lengths in whole-genome sequence self-alignments.
title_short Algebraic distribution of segmental duplication lengths in whole-genome sequence self-alignments.
title_full Algebraic distribution of segmental duplication lengths in whole-genome sequence self-alignments.
title_fullStr Algebraic distribution of segmental duplication lengths in whole-genome sequence self-alignments.
title_full_unstemmed Algebraic distribution of segmental duplication lengths in whole-genome sequence self-alignments.
title_sort algebraic distribution of segmental duplication lengths in whole-genome sequence self-alignments.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2011-01-01
description Distributions of duplicated sequences from genome self-alignment are characterized, including forward and backward alignments in bacteria and eukaryotes. A Markovian process without auto-correlation should generate an exponential distribution expected from local effects of point mutation and selection on localised function; however, the observed distributions show substantial deviation from exponential form--they are roughly algebraic instead--suggesting a novel kind of long-distance correlation that must be non-local in origin.
url http://europepmc.org/articles/PMC3136455?pdf=render
work_keys_str_mv AT kungao algebraicdistributionofsegmentalduplicationlengthsinwholegenomesequenceselfalignments
AT jonathanmiller algebraicdistributionofsegmentalduplicationlengthsinwholegenomesequenceselfalignments
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