Allele Frequencies of HLA Class-I Loci in the Normal Iranian Population

• Main Authors: Andisheh Ghashghaie, Kamran Alimoghaddam, Mohammad Reza Ostadali, Hamid-o-allah Ghaffari, L Khansari, M Sadraee, E Mirrasekhian, Iranna Mohyedin, F Raoofi, Z Noori, H Yaghmaian, H Eshaghi, Ardeshir Ghavamzadeh
• Format: Article
• Language: English
• Published: Tehran University of Medical Sciences 2009-04-01
• Series: International Journal of Hematology-Oncology and Stem Cell Research
• Subjects: HLA, Cord Blood, GvHD, Frequency Transplantation, Donor.
• Online Access: http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/16091.pdf&manuscript_id=16091
• ISSN: 2008-3009; 2008-2207

"nIntroduction: Human Leukocyte Antigen (HLA) genes are the most polymorphic loci in the human genome. They predict the outcome of transplantation by detecting self from non-self antigens. The best use of HLA typing is to find a HLA-match donor for BMT candidate patients. Evidence suggests that matching unrelated donors and recipients for HLA-A, -B and -DRB1 loci is a prediction for an improved outcome. "nMethods and materials: HLA-A and -B of six hundred Iranian cord blood samples were typed by PCR-SSP method and the frequency of loci were estimated. "nResults: The most frequent alleles were A*02(18.16), A*24(16.41), B*35(21.66) and B*51(13.35), respectively. "nDiscussion: Our HLA typing data show similarity between neighbor and related countries and Caucasians. Identifying HLA alleles helps to find suitable donors for patients in need of hematopoietic stem cell transplantation.