Scaffolding LSD1 Inhibitors Impair NK Cell Metabolism and Cytotoxic Function Through Depletion of Glutathione

Scaffolding LSD1 Inhibitors Impair NK Cell Metabolism and Cytotoxic Function Through Depletion of Glutathione

Cell therapies such as chimeric-antigen receptor (CAR) T-cells and NK cells are cutting-edge methods for treating cancer and other diseases. There is high interest in optimizing drug treatment regimens to best work together with emerging cell therapies, such as targeting epigenetic enzymes to stimul...

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Bibliographic Details
Main Authors: Cavan P. Bailey, Mary Figueroa, Achintyan Gangadharan, Dean A. Lee, Joya Chandra
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Immunology
Subjects:
LSD1
NK cell
antioxidant
metabolism
glutathione
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.02196/full

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