Possible Involvement of Tissue Plasminogen Activator/Brain-Derived Neurotrophic Factor Pathway in Anti-Depressant Effects of Electroacupuncture in Chronic Unpredictable Mild Stress-Induced Depression in Rats

Possible Involvement of Tissue Plasminogen Activator/Brain-Derived Neurotrophic Factor Pathway in Anti-Depressant Effects of Electroacupuncture in Chronic Unpredictable Mild Stress-Induced Depression in Rats

ObjectiveUsing a rat model of chronic unpredictable mild stress (CUMS), to investigate the effects of electroacupuncture (EA) on the tissue plasminogen activator (tPA)/brain-derived neurotrophic factor (BDNF) pathway.MethodsSixty male Sprague–Dawley rats were randomly divided into four groups: norma...

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Bibliographic Details
Main Authors: Tong Luo, Huiling Tian, Hongtao Song, Jun Zhao, Ai Liya, Yumin Fang, Junhui Mou, Zhigang Li, Saiyin Chaoketu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Psychiatry
Subjects:
electroacupuncture
hippocampus
raphe nuclei
tPA
BDNF
depression
Online Access:https://www.frontiersin.org/article/10.3389/fpsyt.2020.00063/full

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