Neopterin and 7,8-dihydroneopterin are generated within atherosclerotic plaques

Neopterin and 7,8-dihydroneopterin are generated within atherosclerotic plaques

Plasma neopterin correlates with the level of cardiovascular disease. Neopterin is the oxidation product of 7,8-dihydroneopterin, which is released by γ-interferon-stimulated macrophages. 7,8-Dihydroneopterin is a potent antioxidant, which inhibits lipid oxidation, macrophage cell death and scavenge...

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Bibliographic Details
Main Authors: Janmale Tejraj, Genet Rebecca, Crone Elizabeth, Flavall Elizabeth, Firth Carol, Pirker John, Roake Justin A., Gieseg Steven P.
Format: Article
Language:English
Published: De Gruyter 2015-09-01
Series:Pteridines
Subjects:
7,8-dihydroneopterin
atherosclerosis
lipid peroxide
neopterin
plaque
protein bound dopa
tocopherol
Online Access:https://doi.org/10.1515/pterid-2015-0004

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