Targeting MAPK Signaling in Age-Related Macular Degeneration

Targeting MAPK Signaling in Age-Related Macular Degeneration

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Age-related macular degeneration (AMD) is a major cause of irreversible blindness affecting elderly people in the world. AMD is a complex multifactorial disease associated with demographic, genetics, and environmental risk factors. It is well established that oxidative stress, inflammation, and apop...

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Main Author: Svetlana V. Kyosseva
Format: Article
Language:English
Published: SAGE Publishing 2016-01-01
Series:Ophthalmology and Eye Diseases
Online Access:https://doi.org/10.4137/OED.S32200
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spelling doaj-86b0dd6d1b35432cae4be85a6594714a2020-11-24T23:26:38ZengSAGE PublishingOphthalmology and Eye Diseases1179-17212016-01-01810.4137/OED.S32200Targeting MAPK Signaling in Age-Related Macular DegenerationSvetlana V. Kyosseva0Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.Age-related macular degeneration (AMD) is a major cause of irreversible blindness affecting elderly people in the world. AMD is a complex multifactorial disease associated with demographic, genetics, and environmental risk factors. It is well established that oxidative stress, inflammation, and apoptosis play critical roles in the pathogenesis of AMD. The mitogen-activated protein kinase (MAPK) signaling pathways are activated by diverse extracellular stimuli, including growth factors, mitogens, hormones, cytokines, and different cellular stressors such as oxidative stress. They regulate cell proliferation, differentiation, survival, and apoptosis. This review addresses the novel findings from human and animal studies on the relationship of MAPK signaling with AMD. The use of specific MAPK inhibitors may represent a potential therapeutic target for the treatment of this debilitating eye disease.https://doi.org/10.4137/OED.S32200
collection DOAJ
language English
format Article
sources DOAJ
author Svetlana V. Kyosseva
spellingShingle Svetlana V. Kyosseva
Targeting MAPK Signaling in Age-Related Macular Degeneration
Ophthalmology and Eye Diseases
author_facet Svetlana V. Kyosseva
author_sort Svetlana V. Kyosseva
title Targeting MAPK Signaling in Age-Related Macular Degeneration
title_short Targeting MAPK Signaling in Age-Related Macular Degeneration
title_full Targeting MAPK Signaling in Age-Related Macular Degeneration
title_fullStr Targeting MAPK Signaling in Age-Related Macular Degeneration
title_full_unstemmed Targeting MAPK Signaling in Age-Related Macular Degeneration
title_sort targeting mapk signaling in age-related macular degeneration
publisher SAGE Publishing
series Ophthalmology and Eye Diseases
issn 1179-1721
publishDate 2016-01-01
description Age-related macular degeneration (AMD) is a major cause of irreversible blindness affecting elderly people in the world. AMD is a complex multifactorial disease associated with demographic, genetics, and environmental risk factors. It is well established that oxidative stress, inflammation, and apoptosis play critical roles in the pathogenesis of AMD. The mitogen-activated protein kinase (MAPK) signaling pathways are activated by diverse extracellular stimuli, including growth factors, mitogens, hormones, cytokines, and different cellular stressors such as oxidative stress. They regulate cell proliferation, differentiation, survival, and apoptosis. This review addresses the novel findings from human and animal studies on the relationship of MAPK signaling with AMD. The use of specific MAPK inhibitors may represent a potential therapeutic target for the treatment of this debilitating eye disease.
url https://doi.org/10.4137/OED.S32200
work_keys_str_mv AT svetlanavkyosseva targetingmapksignalinginagerelatedmaculardegeneration
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