Synthesis, structure and solvatochromism of 5-methyl-5-(3- or 4-substituted phenyl)hydantoins

• Main Authors: NATALIJA D. DIVJAK, NEBOJŠA R. BANJAC, NATAŠA V. VALENTIĆ, GORDANA S. UŠĆUMLIĆ
• Format: Article
• Language: English
• Published: Serbian Chemical Society 2009-11-01
• Series: Journal of the Serbian Chemical Society
• Subjects: hydantoins; absorption frequencies; LSER; lipophilicity parameter; specific solvent; interactions; pharmacological activity
• Online Access: http://www.shd.org.rs/JSCS/Vol74/No11/02-4134_3910.pdf
• ISSN: 0352-5139

Several 5-methyl-5-(3- or 4-substituted phenyl)hydantoins were prepared and their ultraviolet absorption spectra were recorded in the region 200–400 nm in twelve solvents of different polarity. The effect of solvent dipo¬larity/polarizability and solvent/solute hydrogen bonding interactions were analyzed by means of the linear solvation energy relationship (LSER) concept proposed by Kamlet and Taft. The lipophilic activity of the investigated hydantoins was estimated by calculation of log P values with Advanced Chemistry Development Software. The calculated values of log P were correlated with the contribution of hydrogen bond donor–solvent interactions. By employing the thus obtained linear dependence, the pharmacological activity of the studied hydantoin derivatives is discussed.