Molecular Characteristics and Treatment of Endothelial Dysfunction in Patients with COPD: A Review Article

Patients with chronic obstructive pulmonary disease (COPD) show systemic consequences, such as chronic systemic inflammation leading to changes in the airway, airway penetrability, and endothelial function. Endothelial dysfunction is characterized by a list of alterations of endothelium towards redu...

Full description

Bibliographic Details
Main Authors: Botond Szucs, Csilla Szucs, Mate Petrekanits, Janos T. Varga
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:International Journal of Molecular Sciences
Subjects:
Online Access:https://www.mdpi.com/1422-0067/20/18/4329
id doaj-86969415b2074142855fb950b16e5591
record_format Article
spelling doaj-86969415b2074142855fb950b16e55912020-11-25T02:01:02ZengMDPI AGInternational Journal of Molecular Sciences1422-00672019-09-012018432910.3390/ijms20184329ijms20184329Molecular Characteristics and Treatment of Endothelial Dysfunction in Patients with COPD: A Review ArticleBotond Szucs0Csilla Szucs1Mate Petrekanits2Janos T. Varga3PharmaFlight Research and Training Center, H-4030 Debrecen, HungaryDepartment of Anatomy, Histology and Embryology, Faculty of Medicine, University of Debrecen, Debrecen H-4032, HungaryInstitute of Exercise Physiology and Sport Medicine, University of Physical Education, H-1123 Budapest, HungaryDepartment of Pulmonary Rehabilitation, National Koranyi Institute for Pulmonology, H-1121 Budapest, HungaryPatients with chronic obstructive pulmonary disease (COPD) show systemic consequences, such as chronic systemic inflammation leading to changes in the airway, airway penetrability, and endothelial function. Endothelial dysfunction is characterized by a list of alterations of endothelium towards reduced vasodilation, proinflammatory state, detachment and apoptosis of endothelial cells, and development of atherosclerosis. COPD-induced endothelial dysfunction is associated with elevated cardiovascular risk. The increment of physical activities such as pulmonary rehabilitation (PR) training have a significant effect on COPD, thus, PR can be an integrative part of COPD treatment. In this narrative review the focus is on the function of endothelial inflammatory mediators [cytokines, chemokines, and cellular proteases] and pulmonary endothelial cells and endothelial dysfunction in COPD as well as the effects of dysfunction of the endothelium may play in COPD-related pulmonary hypertension. The relationship between smoking and endothelial dysfunction is also discussed. The connection between different pulmonary rehabilitation programs, arterial stiffness and pulse wave velocity (PWV) is presented. Endothelial dysfunction is a significant prognostic factor of COPD, which can be characterized by PWV. We discuss future considerations, like training programs, as an important part of the treatment that has a favorable impact on the endothelial function.https://www.mdpi.com/1422-0067/20/18/4329COPDpulmonary rehabilitationendothelial dysfunctioncardiovascular riskpulmonary hypertension
collection DOAJ
language English
format Article
sources DOAJ
author Botond Szucs
Csilla Szucs
Mate Petrekanits
Janos T. Varga
spellingShingle Botond Szucs
Csilla Szucs
Mate Petrekanits
Janos T. Varga
Molecular Characteristics and Treatment of Endothelial Dysfunction in Patients with COPD: A Review Article
International Journal of Molecular Sciences
COPD
pulmonary rehabilitation
endothelial dysfunction
cardiovascular risk
pulmonary hypertension
author_facet Botond Szucs
Csilla Szucs
Mate Petrekanits
Janos T. Varga
author_sort Botond Szucs
title Molecular Characteristics and Treatment of Endothelial Dysfunction in Patients with COPD: A Review Article
title_short Molecular Characteristics and Treatment of Endothelial Dysfunction in Patients with COPD: A Review Article
title_full Molecular Characteristics and Treatment of Endothelial Dysfunction in Patients with COPD: A Review Article
title_fullStr Molecular Characteristics and Treatment of Endothelial Dysfunction in Patients with COPD: A Review Article
title_full_unstemmed Molecular Characteristics and Treatment of Endothelial Dysfunction in Patients with COPD: A Review Article
title_sort molecular characteristics and treatment of endothelial dysfunction in patients with copd: a review article
publisher MDPI AG
series International Journal of Molecular Sciences
issn 1422-0067
publishDate 2019-09-01
description Patients with chronic obstructive pulmonary disease (COPD) show systemic consequences, such as chronic systemic inflammation leading to changes in the airway, airway penetrability, and endothelial function. Endothelial dysfunction is characterized by a list of alterations of endothelium towards reduced vasodilation, proinflammatory state, detachment and apoptosis of endothelial cells, and development of atherosclerosis. COPD-induced endothelial dysfunction is associated with elevated cardiovascular risk. The increment of physical activities such as pulmonary rehabilitation (PR) training have a significant effect on COPD, thus, PR can be an integrative part of COPD treatment. In this narrative review the focus is on the function of endothelial inflammatory mediators [cytokines, chemokines, and cellular proteases] and pulmonary endothelial cells and endothelial dysfunction in COPD as well as the effects of dysfunction of the endothelium may play in COPD-related pulmonary hypertension. The relationship between smoking and endothelial dysfunction is also discussed. The connection between different pulmonary rehabilitation programs, arterial stiffness and pulse wave velocity (PWV) is presented. Endothelial dysfunction is a significant prognostic factor of COPD, which can be characterized by PWV. We discuss future considerations, like training programs, as an important part of the treatment that has a favorable impact on the endothelial function.
topic COPD
pulmonary rehabilitation
endothelial dysfunction
cardiovascular risk
pulmonary hypertension
url https://www.mdpi.com/1422-0067/20/18/4329
work_keys_str_mv AT botondszucs molecularcharacteristicsandtreatmentofendothelialdysfunctioninpatientswithcopdareviewarticle
AT csillaszucs molecularcharacteristicsandtreatmentofendothelialdysfunctioninpatientswithcopdareviewarticle
AT matepetrekanits molecularcharacteristicsandtreatmentofendothelialdysfunctioninpatientswithcopdareviewarticle
AT janostvarga molecularcharacteristicsandtreatmentofendothelialdysfunctioninpatientswithcopdareviewarticle
_version_ 1724959186083643392