Volume expansion and TRPV4 activation regulate stem cell fate in three-dimensional microenvironments

Volume expansion and TRPV4 activation regulate stem cell fate in three-dimensional microenvironments

For mesenchymal stem cells (MSCs), matrix remodeling is associated with enhanced osteogenic differentiation. Here authors find that MSCs in viscoelastic hydrogels exhibit volume expansion during cell spreading, and greater volume expansion is associated with enhanced osteogenesis.

Bibliographic Details
Main Authors: Hong-pyo Lee, Ryan Stowers, Ovijit Chaudhuri
Format: Article
Language:English
Published: Nature Publishing Group 2019-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-08465-x
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spelling doaj-86911035bc2748da8dab6100140e824a2021-05-11T12:14:32ZengNature Publishing GroupNature Communications2041-17232019-01-0110111310.1038/s41467-019-08465-xVolume expansion and TRPV4 activation regulate stem cell fate in three-dimensional microenvironmentsHong-pyo Lee0Ryan Stowers1Ovijit Chaudhuri2Department of Mechanical Engineering, Stanford UniversityDepartment of Mechanical Engineering, Stanford UniversityDepartment of Mechanical Engineering, Stanford UniversityFor mesenchymal stem cells (MSCs), matrix remodeling is associated with enhanced osteogenic differentiation. Here authors find that MSCs in viscoelastic hydrogels exhibit volume expansion during cell spreading, and greater volume expansion is associated with enhanced osteogenesis.https://doi.org/10.1038/s41467-019-08465-x
collection DOAJ
language English
format Article
sources DOAJ
author Hong-pyo Lee
Ryan Stowers
Ovijit Chaudhuri
spellingShingle Hong-pyo Lee
Ryan Stowers
Ovijit Chaudhuri
Volume expansion and TRPV4 activation regulate stem cell fate in three-dimensional microenvironments
Nature Communications
author_facet Hong-pyo Lee
Ryan Stowers
Ovijit Chaudhuri
author_sort Hong-pyo Lee
title Volume expansion and TRPV4 activation regulate stem cell fate in three-dimensional microenvironments
title_short Volume expansion and TRPV4 activation regulate stem cell fate in three-dimensional microenvironments
title_full Volume expansion and TRPV4 activation regulate stem cell fate in three-dimensional microenvironments
title_fullStr Volume expansion and TRPV4 activation regulate stem cell fate in three-dimensional microenvironments
title_full_unstemmed Volume expansion and TRPV4 activation regulate stem cell fate in three-dimensional microenvironments
title_sort volume expansion and trpv4 activation regulate stem cell fate in three-dimensional microenvironments
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-01-01
description For mesenchymal stem cells (MSCs), matrix remodeling is associated with enhanced osteogenic differentiation. Here authors find that MSCs in viscoelastic hydrogels exhibit volume expansion during cell spreading, and greater volume expansion is associated with enhanced osteogenesis.
url https://doi.org/10.1038/s41467-019-08465-x
work_keys_str_mv AT hongpyolee volumeexpansionandtrpv4activationregulatestemcellfateinthreedimensionalmicroenvironments
AT ryanstowers volumeexpansionandtrpv4activationregulatestemcellfateinthreedimensionalmicroenvironments
AT ovijitchaudhuri volumeexpansionandtrpv4activationregulatestemcellfateinthreedimensionalmicroenvironments
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