Discovery of Novel Bovine Viral Diarrhea Inhibitors Using Structure-Based Virtual Screening on the Envelope Protein E2

Discovery of Novel Bovine Viral Diarrhea Inhibitors Using Structure-Based Virtual Screening on the Envelope Protein E2

Bovine viral diarrhea virus (BVDV) is a member of the genus Pestivirus within the family Flaviviridae. BVDV causes both acute and persistent infections in cattle, leading to substantial financial losses to the livestock industry each year. The global prevalence of persistent BVDV infection and the l...

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Bibliographic Details
Main Authors: Mariela Bollini, Emilse S. Leal, Natalia S. Adler, María G. Aucar, Gabriela A. Fernández, María J. Pascual, Fernando Merwaiss, Diego E. Alvarez, Claudio N. Cavasotto
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Chemistry
Subjects:
BVDV entry inhibitors
structure-based virtual screening
molecular dynamics simulation
envelope protein
molecular docking
Online Access:http://journal.frontiersin.org/article/10.3389/fchem.2018.00079/full

Internet

http://journal.frontiersin.org/article/10.3389/fchem.2018.00079/full

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