Juxtacrine Activity of Estrogen Receptor α in Uterine Stromal Cells is Necessary for Estrogen-Induced Epithelial Cell Proliferation

Abstract Aberrant regulation of uterine cell growth can lead to endometrial cancer and infertility. To understand the molecular mechanisms of estrogen-induced uterine cell growth, we removed the estrogen receptor α (Esr1) from mouse uterine stromal cells, where the embryo is implanted during pregnan...

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Main Authors:	Wipawee Winuthayanon, Sydney L. Lierz, Karena C. Delarosa, Skylar R. Sampels, Lauren J. Donoghue, Sylvia C. Hewitt, Kenneth S. Korach
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-08-01
Series:	Scientific Reports
Online Access:	https://doi.org/10.1038/s41598-017-07728-1

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spelling	doaj-8688e9eb254b477c9b007249a18d3a502020-12-08T00:51:09ZengNature Publishing GroupScientific Reports2045-23222017-08-017111510.1038/s41598-017-07728-1Juxtacrine Activity of Estrogen Receptor α in Uterine Stromal Cells is Necessary for Estrogen-Induced Epithelial Cell ProliferationWipawee Winuthayanon0Sydney L. Lierz1Karena C. Delarosa2Skylar R. Sampels3Lauren J. Donoghue4Sylvia C. Hewitt5Kenneth S. Korach6School of Molecular Biosciences, Center for Reproductive Biology, College of Veterinary Medicine, Washington State UniversityReproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle ParkSchool of Molecular Biosciences, Center for Reproductive Biology, College of Veterinary Medicine, Washington State UniversitySchool of Molecular Biosciences, Center for Reproductive Biology, College of Veterinary Medicine, Washington State UniversityReproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle ParkReproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle ParkReproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle ParkAbstract Aberrant regulation of uterine cell growth can lead to endometrial cancer and infertility. To understand the molecular mechanisms of estrogen-induced uterine cell growth, we removed the estrogen receptor α (Esr1) from mouse uterine stromal cells, where the embryo is implanted during pregnancy. Without ESR1 in neighboring stroma cells, epithelial cells that line the inside of the uterus are unable to grow due to a lack of growth factors secreted from adjacent stromal cells. Moreover, loss of stromal ESR1 caused mice to deliver fewer pups due in part due to inability of some embryos to implant in the uterus, indicating that stromal ESR1 is crucial for uterine cell growth and pregnancy.https://doi.org/10.1038/s41598-017-07728-1
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Wipawee Winuthayanon Sydney L. Lierz Karena C. Delarosa Skylar R. Sampels Lauren J. Donoghue Sylvia C. Hewitt Kenneth S. Korach
spellingShingle	Wipawee Winuthayanon Sydney L. Lierz Karena C. Delarosa Skylar R. Sampels Lauren J. Donoghue Sylvia C. Hewitt Kenneth S. Korach Juxtacrine Activity of Estrogen Receptor α in Uterine Stromal Cells is Necessary for Estrogen-Induced Epithelial Cell Proliferation Scientific Reports
author_facet	Wipawee Winuthayanon Sydney L. Lierz Karena C. Delarosa Skylar R. Sampels Lauren J. Donoghue Sylvia C. Hewitt Kenneth S. Korach
author_sort	Wipawee Winuthayanon
title	Juxtacrine Activity of Estrogen Receptor α in Uterine Stromal Cells is Necessary for Estrogen-Induced Epithelial Cell Proliferation
title_short	Juxtacrine Activity of Estrogen Receptor α in Uterine Stromal Cells is Necessary for Estrogen-Induced Epithelial Cell Proliferation
title_full	Juxtacrine Activity of Estrogen Receptor α in Uterine Stromal Cells is Necessary for Estrogen-Induced Epithelial Cell Proliferation
title_fullStr	Juxtacrine Activity of Estrogen Receptor α in Uterine Stromal Cells is Necessary for Estrogen-Induced Epithelial Cell Proliferation
title_full_unstemmed	Juxtacrine Activity of Estrogen Receptor α in Uterine Stromal Cells is Necessary for Estrogen-Induced Epithelial Cell Proliferation
title_sort	juxtacrine activity of estrogen receptor α in uterine stromal cells is necessary for estrogen-induced epithelial cell proliferation
publisher	Nature Publishing Group
series	Scientific Reports
issn	2045-2322
publishDate	2017-08-01
description	Abstract Aberrant regulation of uterine cell growth can lead to endometrial cancer and infertility. To understand the molecular mechanisms of estrogen-induced uterine cell growth, we removed the estrogen receptor α (Esr1) from mouse uterine stromal cells, where the embryo is implanted during pregnancy. Without ESR1 in neighboring stroma cells, epithelial cells that line the inside of the uterus are unable to grow due to a lack of growth factors secreted from adjacent stromal cells. Moreover, loss of stromal ESR1 caused mice to deliver fewer pups due in part due to inability of some embryos to implant in the uterus, indicating that stromal ESR1 is crucial for uterine cell growth and pregnancy.
url	https://doi.org/10.1038/s41598-017-07728-1
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Juxtacrine Activity of Estrogen Receptor α in Uterine Stromal Cells is Necessary for Estrogen-Induced Epithelial Cell Proliferation

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