Design, synthesis and biological evaluation of antimalarial activity of new derivatives of 2,4,6-s-triazine

Design, synthesis and biological evaluation of antimalarial activity of new derivatives of 2,4,6-s-triazine

Abstract Dihydrofolate reductase (DHFR) is an important enzyme for de novo synthesis of nucleotides in Plasmodium falciparum and it is essential for cell proliferation. DHFR is a well known antimalarial target for drugs like cycloguanil and pyrimethamine which target its inhibition for their pharmac...

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Bibliographic Details
Main Authors: Mallika Pathak, Himanshu Ojha, Anjani K. Tiwari, Deepti Sharma, Manisha Saini, Rita Kakkar
Format: Article
Language:English
Published: BMC 2017-12-01
Series:Chemistry Central Journal
Subjects:
Antimalarial
DHFR inhibitors
Molecular docking
s-Triazine
3D7 strain
Online Access:http://link.springer.com/article/10.1186/s13065-017-0362-5

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http://link.springer.com/article/10.1186/s13065-017-0362-5

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