Detection of anti-protease inhibitors resistance mutations in HCV strains infecting treatment-naïve chronic patients from Romania

Detection of anti-protease inhibitors resistance mutations in HCV strains infecting treatment-naïve chronic patients from Romania

Background: Severe complications of chronic hepatitis C – i.e. cirrhosis and hepatocellular carcinoma – are important causes of morbidity and mortality worldwide. Despite the overwhelming rates of sustained virologic response achieved after therapy with different combinations of direct-acting antivi...

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Main Authors: Dinu Sorin, Țârdei Grațiela, Ceaușu Emanoil, Florescu Simin Aysel, Micu Laurențiu, Ecobici Alina Monica, Mihăilă Mariana, Oprișan Gabriela
Format: Article
Language:English
Published: Sciendo 2018-10-01
Series:Romanian Journal of Laboratory Medicine
Subjects:
ns3 protease
direct-acting antivirals
resistance mutations
naïve to treatment patients
Online Access:https://doi.org/10.2478/rrlm-2018-0029
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spelling doaj-8672c020a2914c868fff426ec0a8e2762021-09-05T14:01:30ZengSciendoRomanian Journal of Laboratory Medicine2284-56232018-10-0126444344910.2478/rrlm-2018-0029rrlm-2018-0029Detection of anti-protease inhibitors resistance mutations in HCV strains infecting treatment-naïve chronic patients from RomaniaDinu Sorin0Țârdei Grațiela1Ceaușu Emanoil2Florescu Simin Aysel3Micu Laurențiu4Ecobici Alina Monica5Mihăilă Mariana6Oprișan Gabriela7Molecular Epidemiology Laboratory, Cantacuzino National Medico-Military Institute for Research and Development, Bucharest, Romania; Earth, Environmental and Life Sciences Division, The Research Institute of the University of Bucharest (ICUB), Bucharest, Romania“Dr Victor Babeş” Clinical Hospital for Infectious and Tropical Diseases, Bucharest, Romania“Dr Victor Babeş” Clinical Hospital for Infectious and Tropical Diseases, Bucharest, Romania“Dr Victor Babeş” Clinical Hospital for Infectious and Tropical Diseases, Bucharest, RomaniaFundeni Clinical Institute, Bucharest, RomaniaFundeni Clinical Institute, Bucharest, RomaniaFundeni Clinical Institute, Bucharest, RomaniaMolecular Epidemiology Laboratory, Cantacuzino National Medico-Military Institute for Research and Development, Bucharest, Romania; Faculty of Pharmacy, Titu Maiorescu University, Bucharest, RomaniaBackground: Severe complications of chronic hepatitis C – i.e. cirrhosis and hepatocellular carcinoma – are important causes of morbidity and mortality worldwide. Despite the overwhelming rates of sustained virologic response achieved after therapy with different combinations of direct-acting antiviral drugs (DAAs), treatment failure is still recorded, and is due to the mutations harboured by hepatitis C virus (HCV) resistance associated variants (RAVs) selected during therapy. Baseline RAVs testing was found significant for guiding treatment in the cases of treatment failure and, sometimes, in naïve patients.https://doi.org/10.2478/rrlm-2018-0029ns3 proteasedirect-acting antiviralsresistance mutationsnaïve to treatment patients
collection DOAJ
language English
format Article
sources DOAJ
author Dinu Sorin
Țârdei Grațiela
Ceaușu Emanoil
Florescu Simin Aysel
Micu Laurențiu
Ecobici Alina Monica
Mihăilă Mariana
Oprișan Gabriela
spellingShingle Dinu Sorin
Țârdei Grațiela
Ceaușu Emanoil
Florescu Simin Aysel
Micu Laurențiu
Ecobici Alina Monica
Mihăilă Mariana
Oprișan Gabriela
Detection of anti-protease inhibitors resistance mutations in HCV strains infecting treatment-naïve chronic patients from Romania
Romanian Journal of Laboratory Medicine
ns3 protease
direct-acting antivirals
resistance mutations
naïve to treatment patients
author_facet Dinu Sorin
Țârdei Grațiela
Ceaușu Emanoil
Florescu Simin Aysel
Micu Laurențiu
Ecobici Alina Monica
Mihăilă Mariana
Oprișan Gabriela
author_sort Dinu Sorin
title Detection of anti-protease inhibitors resistance mutations in HCV strains infecting treatment-naïve chronic patients from Romania
title_short Detection of anti-protease inhibitors resistance mutations in HCV strains infecting treatment-naïve chronic patients from Romania
title_full Detection of anti-protease inhibitors resistance mutations in HCV strains infecting treatment-naïve chronic patients from Romania
title_fullStr Detection of anti-protease inhibitors resistance mutations in HCV strains infecting treatment-naïve chronic patients from Romania
title_full_unstemmed Detection of anti-protease inhibitors resistance mutations in HCV strains infecting treatment-naïve chronic patients from Romania
title_sort detection of anti-protease inhibitors resistance mutations in hcv strains infecting treatment-naïve chronic patients from romania
publisher Sciendo
series Romanian Journal of Laboratory Medicine
issn 2284-5623
publishDate 2018-10-01
description Background: Severe complications of chronic hepatitis C – i.e. cirrhosis and hepatocellular carcinoma – are important causes of morbidity and mortality worldwide. Despite the overwhelming rates of sustained virologic response achieved after therapy with different combinations of direct-acting antiviral drugs (DAAs), treatment failure is still recorded, and is due to the mutations harboured by hepatitis C virus (HCV) resistance associated variants (RAVs) selected during therapy. Baseline RAVs testing was found significant for guiding treatment in the cases of treatment failure and, sometimes, in naïve patients.
topic ns3 protease
direct-acting antivirals
resistance mutations
naïve to treatment patients
url https://doi.org/10.2478/rrlm-2018-0029
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