Role of Myeloid Cells in Oncolytic Reovirus-Based Cancer Therapy

Role of Myeloid Cells in Oncolytic Reovirus-Based Cancer Therapy

Oncolytic reovirus preferentially targets and kills cancer cells via the process of oncolysis, and additionally drives clinically favorable antitumor T cell responses that form protective immunological memory against cancer relapse. This two-prong attack by reovirus on cancers constitutes the founda...

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Bibliographic Details
Main Authors: Vishnupriyan Kumar, Michael A. A. Giacomantonio, Shashi Gujar
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Viruses
Subjects:
reovirus
oncolytic virus
myeloid cell plasticity
tumor-associated macrophages
myeloid-derived suppressor cells
tumor microenvironment
Online Access:https://www.mdpi.com/1999-4915/13/4/654

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