The urinary cytokine/chemokine signature of renal hyperfiltration in adolescents with type 1 diabetes.

Urinary cytokine/chemokine levels are elevated in adults with type 1 diabetes (T1D) exhibiting renal hyperfiltration. Whether this observation extends to adolescents with T1D remains unknown. Our first objective was to determine the relationship between hyperfiltration and urinary cytokines/chemokin...

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Main Authors: Ron L H Har, Heather N Reich, James W Scholey, Denis Daneman, David B Dunger, Rahim Moineddin, R Neil Dalton, Laura Motran, Yesmino Elia, Livia Deda, Masha Ostrovsky, Etienne B Sochett, Farid H Mahmud, David Z I Cherney
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4230911?pdf=render
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spelling doaj-865732ad8e224bb182c7af242a22c9a42020-11-24T22:12:41ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-01911e11113110.1371/journal.pone.0111131The urinary cytokine/chemokine signature of renal hyperfiltration in adolescents with type 1 diabetes.Ron L H HarHeather N ReichJames W ScholeyDenis DanemanDavid B DungerRahim MoineddinR Neil DaltonLaura MotranYesmino EliaLivia DedaMasha OstrovskyEtienne B SochettFarid H MahmudDavid Z I CherneyUrinary cytokine/chemokine levels are elevated in adults with type 1 diabetes (T1D) exhibiting renal hyperfiltration. Whether this observation extends to adolescents with T1D remains unknown. Our first objective was to determine the relationship between hyperfiltration and urinary cytokines/chemokines in normotensive, normoalbuminuric adolescents with T1D using GFR(cystatin). Our second aim was to determine the relationship between urine and plasma levels of inflammatory biomarkers, to clarify the origin of these factors.Urine and serum cytokines/chemokines (Luminex platform) and GFR(cystatin) were measured in normofiltering (n = 111, T1D-N, GFR<135 ml/min/1.73 m(2)) and hyperfiltering (n = 31, T1D-H, GFR ≥ 135 ml/min/1.73 m(2)) adolescents with T1D (ages 10-16), and in age and sex matched healthy control subjects (HC, n = 59).We noted significant step-wise increases in urinary cytokine/chemokine excretion according to filtration status with highest levels in T1D-H, with parallel trends in serum analyte concentrations. After adjusting for serum glucose at the time of sampling, differences in urinary cytokine excretion were not statistically significant. Only serum IL-2 significantly differed between HC and T1D (p = 0.0076).Hyperfiltration is associated with increased urinary cytokine/chemokine excretion in T1D adolescents, and parallel trends in serum cytokine concentration. The GFR-associated trends in cytokine excretion may be driven by the effects of ambient hyperglycemia. The relationship between hyperfiltration, glycemia, and variations in serum and urine cytokine expression and their impact on future renal and systemic vascular complications requires further study.http://europepmc.org/articles/PMC4230911?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Ron L H Har
Heather N Reich
James W Scholey
Denis Daneman
David B Dunger
Rahim Moineddin
R Neil Dalton
Laura Motran
Yesmino Elia
Livia Deda
Masha Ostrovsky
Etienne B Sochett
Farid H Mahmud
David Z I Cherney
spellingShingle Ron L H Har
Heather N Reich
James W Scholey
Denis Daneman
David B Dunger
Rahim Moineddin
R Neil Dalton
Laura Motran
Yesmino Elia
Livia Deda
Masha Ostrovsky
Etienne B Sochett
Farid H Mahmud
David Z I Cherney
The urinary cytokine/chemokine signature of renal hyperfiltration in adolescents with type 1 diabetes.
PLoS ONE
author_facet Ron L H Har
Heather N Reich
James W Scholey
Denis Daneman
David B Dunger
Rahim Moineddin
R Neil Dalton
Laura Motran
Yesmino Elia
Livia Deda
Masha Ostrovsky
Etienne B Sochett
Farid H Mahmud
David Z I Cherney
author_sort Ron L H Har
title The urinary cytokine/chemokine signature of renal hyperfiltration in adolescents with type 1 diabetes.
title_short The urinary cytokine/chemokine signature of renal hyperfiltration in adolescents with type 1 diabetes.
title_full The urinary cytokine/chemokine signature of renal hyperfiltration in adolescents with type 1 diabetes.
title_fullStr The urinary cytokine/chemokine signature of renal hyperfiltration in adolescents with type 1 diabetes.
title_full_unstemmed The urinary cytokine/chemokine signature of renal hyperfiltration in adolescents with type 1 diabetes.
title_sort urinary cytokine/chemokine signature of renal hyperfiltration in adolescents with type 1 diabetes.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2014-01-01
description Urinary cytokine/chemokine levels are elevated in adults with type 1 diabetes (T1D) exhibiting renal hyperfiltration. Whether this observation extends to adolescents with T1D remains unknown. Our first objective was to determine the relationship between hyperfiltration and urinary cytokines/chemokines in normotensive, normoalbuminuric adolescents with T1D using GFR(cystatin). Our second aim was to determine the relationship between urine and plasma levels of inflammatory biomarkers, to clarify the origin of these factors.Urine and serum cytokines/chemokines (Luminex platform) and GFR(cystatin) were measured in normofiltering (n = 111, T1D-N, GFR<135 ml/min/1.73 m(2)) and hyperfiltering (n = 31, T1D-H, GFR ≥ 135 ml/min/1.73 m(2)) adolescents with T1D (ages 10-16), and in age and sex matched healthy control subjects (HC, n = 59).We noted significant step-wise increases in urinary cytokine/chemokine excretion according to filtration status with highest levels in T1D-H, with parallel trends in serum analyte concentrations. After adjusting for serum glucose at the time of sampling, differences in urinary cytokine excretion were not statistically significant. Only serum IL-2 significantly differed between HC and T1D (p = 0.0076).Hyperfiltration is associated with increased urinary cytokine/chemokine excretion in T1D adolescents, and parallel trends in serum cytokine concentration. The GFR-associated trends in cytokine excretion may be driven by the effects of ambient hyperglycemia. The relationship between hyperfiltration, glycemia, and variations in serum and urine cytokine expression and their impact on future renal and systemic vascular complications requires further study.
url http://europepmc.org/articles/PMC4230911?pdf=render
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