Sample size requirements for case-control study designs
<p>Abstract</p> <p>Background</p> <p>Published formulas for case-control designs provide sample sizes required to determine that a given disease-exposure odds ratio is significantly different from one, adjusting for a potential confounder and possible interaction.</p...
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| Format: | Article |
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BMC
2001-11-01
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| Series: | BMC Medical Research Methodology |
| Online Access: | http://www.biomedcentral.com/1471-2288/1/11 |
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doaj-86565eea18134b1593a00c8cd9add5302020-11-24T21:17:52ZengBMCBMC Medical Research Methodology1471-22882001-11-01111110.1186/1471-2288-1-11Sample size requirements for case-control study designsEdwardes Michael D<p>Abstract</p> <p>Background</p> <p>Published formulas for case-control designs provide sample sizes required to determine that a given disease-exposure odds ratio is significantly different from one, adjusting for a potential confounder and possible interaction.</p> <p>Results</p> <p>The formulas are extended from one control per case to <it>F</it> controls per case and adjusted for a potential multi-category confounder in unmatched or matched designs. Interactive FORTRAN programs are described which compute the formulas. The effect of potential disease-exposure-confounder interaction may be explored.</p> <p>Conclusions</p> <p>Software is now available for computing adjusted sample sizes for case-control designs.</p> http://www.biomedcentral.com/1471-2288/1/11 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Edwardes Michael D |
| spellingShingle |
Edwardes Michael D Sample size requirements for case-control study designs BMC Medical Research Methodology |
| author_facet |
Edwardes Michael D |
| author_sort |
Edwardes Michael D |
| title |
Sample size requirements for case-control study designs |
| title_short |
Sample size requirements for case-control study designs |
| title_full |
Sample size requirements for case-control study designs |
| title_fullStr |
Sample size requirements for case-control study designs |
| title_full_unstemmed |
Sample size requirements for case-control study designs |
| title_sort |
sample size requirements for case-control study designs |
| publisher |
BMC |
| series |
BMC Medical Research Methodology |
| issn |
1471-2288 |
| publishDate |
2001-11-01 |
| description |
<p>Abstract</p> <p>Background</p> <p>Published formulas for case-control designs provide sample sizes required to determine that a given disease-exposure odds ratio is significantly different from one, adjusting for a potential confounder and possible interaction.</p> <p>Results</p> <p>The formulas are extended from one control per case to <it>F</it> controls per case and adjusted for a potential multi-category confounder in unmatched or matched designs. Interactive FORTRAN programs are described which compute the formulas. The effect of potential disease-exposure-confounder interaction may be explored.</p> <p>Conclusions</p> <p>Software is now available for computing adjusted sample sizes for case-control designs.</p> |
| url |
http://www.biomedcentral.com/1471-2288/1/11 |
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