Sample size requirements for case-control study designs
<p>Abstract</p> <p>Background</p> <p>Published formulas for case-control designs provide sample sizes required to determine that a given disease-exposure odds ratio is significantly different from one, adjusting for a potential confounder and possible interaction.</p...
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| Format: | Article |
| Language: | English |
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BMC
2001-11-01
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| Series: | BMC Medical Research Methodology |
| Online Access: | http://www.biomedcentral.com/1471-2288/1/11 |
| Summary: | <p>Abstract</p> <p>Background</p> <p>Published formulas for case-control designs provide sample sizes required to determine that a given disease-exposure odds ratio is significantly different from one, adjusting for a potential confounder and possible interaction.</p> <p>Results</p> <p>The formulas are extended from one control per case to <it>F</it> controls per case and adjusted for a potential multi-category confounder in unmatched or matched designs. Interactive FORTRAN programs are described which compute the formulas. The effect of potential disease-exposure-confounder interaction may be explored.</p> <p>Conclusions</p> <p>Software is now available for computing adjusted sample sizes for case-control designs.</p> |
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| ISSN: | 1471-2288 |