Interactions between hydatid cyst and regulated cell death may provide new therapeutic opportunities

Cystic echinococcosis and alveolar echinococcosis are chronic zoonotic infections, transmitted throughout the world. Development of the cestode larval stages in the liver and lungs causes damage to intermediate hosts, including humans. Several pathways leading to the suppression of host immune respo...

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Main Authors: Moghaddam Sirous Mehrani, Picot Stephane, Ahmadpour Ehsan
Format: Article
Language:English
Published: EDP Sciences 2019-01-01
Series:Parasite
Subjects:
Online Access:https://www.parasite-journal.org/articles/parasite/full_html/2019/01/parasite180136/parasite180136.html
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spelling doaj-8644047ec4124e91bd1921e945756de52021-04-02T17:16:15ZengEDP SciencesParasite1776-10422019-01-01267010.1051/parasite/2019070parasite180136Interactions between hydatid cyst and regulated cell death may provide new therapeutic opportunitiesMoghaddam Sirous MehraniPicot Stephanehttps://orcid.org/0000-0002-5735-6759Ahmadpour EhsanCystic echinococcosis and alveolar echinococcosis are chronic zoonotic infections, transmitted throughout the world. Development of the cestode larval stages in the liver and lungs causes damage to intermediate hosts, including humans. Several pathways leading to the suppression of host immune response and the survival of the cysts in various hosts are known. Immune response modulation and regulated cell death (RCD) play a fundamental role in cyst formation, development and pathogenesis. RCD, referring to apoptosis, necrosis and autophagy, can be triggered either via intrinsic or extrinsic cell stimuli. In this review, we provide a general overview of current knowledge on the process of RCD during echinococcosis. The study of interactions between RCD and Echinococcus spp. metacestodes may provide in-depth understanding of echinococcosis pathogenesis and open new horizons for human intervention and treatment of the disease.https://www.parasite-journal.org/articles/parasite/full_html/2019/01/parasite180136/parasite180136.htmlechinococcosishydatid cystregulated cell deathapoptosisnecrosisautophagy
collection DOAJ
language English
format Article
sources DOAJ
author Moghaddam Sirous Mehrani
Picot Stephane
Ahmadpour Ehsan
spellingShingle Moghaddam Sirous Mehrani
Picot Stephane
Ahmadpour Ehsan
Interactions between hydatid cyst and regulated cell death may provide new therapeutic opportunities
Parasite
echinococcosis
hydatid cyst
regulated cell death
apoptosis
necrosis
autophagy
author_facet Moghaddam Sirous Mehrani
Picot Stephane
Ahmadpour Ehsan
author_sort Moghaddam Sirous Mehrani
title Interactions between hydatid cyst and regulated cell death may provide new therapeutic opportunities
title_short Interactions between hydatid cyst and regulated cell death may provide new therapeutic opportunities
title_full Interactions between hydatid cyst and regulated cell death may provide new therapeutic opportunities
title_fullStr Interactions between hydatid cyst and regulated cell death may provide new therapeutic opportunities
title_full_unstemmed Interactions between hydatid cyst and regulated cell death may provide new therapeutic opportunities
title_sort interactions between hydatid cyst and regulated cell death may provide new therapeutic opportunities
publisher EDP Sciences
series Parasite
issn 1776-1042
publishDate 2019-01-01
description Cystic echinococcosis and alveolar echinococcosis are chronic zoonotic infections, transmitted throughout the world. Development of the cestode larval stages in the liver and lungs causes damage to intermediate hosts, including humans. Several pathways leading to the suppression of host immune response and the survival of the cysts in various hosts are known. Immune response modulation and regulated cell death (RCD) play a fundamental role in cyst formation, development and pathogenesis. RCD, referring to apoptosis, necrosis and autophagy, can be triggered either via intrinsic or extrinsic cell stimuli. In this review, we provide a general overview of current knowledge on the process of RCD during echinococcosis. The study of interactions between RCD and Echinococcus spp. metacestodes may provide in-depth understanding of echinococcosis pathogenesis and open new horizons for human intervention and treatment of the disease.
topic echinococcosis
hydatid cyst
regulated cell death
apoptosis
necrosis
autophagy
url https://www.parasite-journal.org/articles/parasite/full_html/2019/01/parasite180136/parasite180136.html
work_keys_str_mv AT moghaddamsirousmehrani interactionsbetweenhydatidcystandregulatedcelldeathmayprovidenewtherapeuticopportunities
AT picotstephane interactionsbetweenhydatidcystandregulatedcelldeathmayprovidenewtherapeuticopportunities
AT ahmadpourehsan interactionsbetweenhydatidcystandregulatedcelldeathmayprovidenewtherapeuticopportunities
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