Interactions between hydatid cyst and regulated cell death may provide new therapeutic opportunities
Cystic echinococcosis and alveolar echinococcosis are chronic zoonotic infections, transmitted throughout the world. Development of the cestode larval stages in the liver and lungs causes damage to intermediate hosts, including humans. Several pathways leading to the suppression of host immune respo...
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2019-01-01
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doaj-8644047ec4124e91bd1921e945756de52021-04-02T17:16:15ZengEDP SciencesParasite1776-10422019-01-01267010.1051/parasite/2019070parasite180136Interactions between hydatid cyst and regulated cell death may provide new therapeutic opportunitiesMoghaddam Sirous MehraniPicot Stephanehttps://orcid.org/0000-0002-5735-6759Ahmadpour EhsanCystic echinococcosis and alveolar echinococcosis are chronic zoonotic infections, transmitted throughout the world. Development of the cestode larval stages in the liver and lungs causes damage to intermediate hosts, including humans. Several pathways leading to the suppression of host immune response and the survival of the cysts in various hosts are known. Immune response modulation and regulated cell death (RCD) play a fundamental role in cyst formation, development and pathogenesis. RCD, referring to apoptosis, necrosis and autophagy, can be triggered either via intrinsic or extrinsic cell stimuli. In this review, we provide a general overview of current knowledge on the process of RCD during echinococcosis. The study of interactions between RCD and Echinococcus spp. metacestodes may provide in-depth understanding of echinococcosis pathogenesis and open new horizons for human intervention and treatment of the disease.https://www.parasite-journal.org/articles/parasite/full_html/2019/01/parasite180136/parasite180136.htmlechinococcosishydatid cystregulated cell deathapoptosisnecrosisautophagy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Moghaddam Sirous Mehrani Picot Stephane Ahmadpour Ehsan |
spellingShingle |
Moghaddam Sirous Mehrani Picot Stephane Ahmadpour Ehsan Interactions between hydatid cyst and regulated cell death may provide new therapeutic opportunities Parasite echinococcosis hydatid cyst regulated cell death apoptosis necrosis autophagy |
author_facet |
Moghaddam Sirous Mehrani Picot Stephane Ahmadpour Ehsan |
author_sort |
Moghaddam Sirous Mehrani |
title |
Interactions between hydatid cyst and regulated cell death may provide new therapeutic opportunities |
title_short |
Interactions between hydatid cyst and regulated cell death may provide new therapeutic opportunities |
title_full |
Interactions between hydatid cyst and regulated cell death may provide new therapeutic opportunities |
title_fullStr |
Interactions between hydatid cyst and regulated cell death may provide new therapeutic opportunities |
title_full_unstemmed |
Interactions between hydatid cyst and regulated cell death may provide new therapeutic opportunities |
title_sort |
interactions between hydatid cyst and regulated cell death may provide new therapeutic opportunities |
publisher |
EDP Sciences |
series |
Parasite |
issn |
1776-1042 |
publishDate |
2019-01-01 |
description |
Cystic echinococcosis and alveolar echinococcosis are chronic zoonotic infections, transmitted throughout the world. Development of the cestode larval stages in the liver and lungs causes damage to intermediate hosts, including humans. Several pathways leading to the suppression of host immune response and the survival of the cysts in various hosts are known. Immune response modulation and regulated cell death (RCD) play a fundamental role in cyst formation, development and pathogenesis. RCD, referring to apoptosis, necrosis and autophagy, can be triggered either via intrinsic or extrinsic cell stimuli. In this review, we provide a general overview of current knowledge on the process of RCD during echinococcosis. The study of interactions between RCD and Echinococcus spp. metacestodes may provide in-depth understanding of echinococcosis pathogenesis and open new horizons for human intervention and treatment of the disease. |
topic |
echinococcosis hydatid cyst regulated cell death apoptosis necrosis autophagy |
url |
https://www.parasite-journal.org/articles/parasite/full_html/2019/01/parasite180136/parasite180136.html |
work_keys_str_mv |
AT moghaddamsirousmehrani interactionsbetweenhydatidcystandregulatedcelldeathmayprovidenewtherapeuticopportunities AT picotstephane interactionsbetweenhydatidcystandregulatedcelldeathmayprovidenewtherapeuticopportunities AT ahmadpourehsan interactionsbetweenhydatidcystandregulatedcelldeathmayprovidenewtherapeuticopportunities |
_version_ |
1721554331346403328 |