Macropinocytosis drives T cell growth by sustaining the activation of mTORC1

Macropinocytosis has been implicated in the expansion of transformed cells when nutrient-depleted. Here the authors show that macropinocytosis also contributes to the expansion of primary T cells even under nutrient-replete conditions, potentially by providing access of extracellular amino acids to...

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Main Authors:	John C. Charpentier, Di Chen, Philip E. Lapinski, Jackson Turner, Irina Grigorova, Joel A. Swanson, Philip D. King
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-13997-3

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spelling	doaj-863ae641e6d64e65b74baab500a58bce2021-05-11T08:08:16ZengNature Publishing GroupNature Communications2041-17232020-01-011111910.1038/s41467-019-13997-3Macropinocytosis drives T cell growth by sustaining the activation of mTORC1John C. Charpentier0Di Chen1Philip E. Lapinski2Jackson Turner3Irina Grigorova4Joel A. Swanson5Philip D. King6Department of Microbiology and Immunology, University of Michigan Medical SchoolDepartment of Microbiology and Immunology, University of Michigan Medical SchoolDepartment of Microbiology and Immunology, University of Michigan Medical SchoolDepartment of Microbiology and Immunology, University of Michigan Medical SchoolDepartment of Microbiology and Immunology, University of Michigan Medical SchoolDepartment of Microbiology and Immunology, University of Michigan Medical SchoolDepartment of Microbiology and Immunology, University of Michigan Medical SchoolMacropinocytosis has been implicated in the expansion of transformed cells when nutrient-depleted. Here the authors show that macropinocytosis also contributes to the expansion of primary T cells even under nutrient-replete conditions, potentially by providing access of extracellular amino acids to an endolysosomal compartment to sustain mTORC1 activation.https://doi.org/10.1038/s41467-019-13997-3
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	John C. Charpentier Di Chen Philip E. Lapinski Jackson Turner Irina Grigorova Joel A. Swanson Philip D. King
spellingShingle	John C. Charpentier Di Chen Philip E. Lapinski Jackson Turner Irina Grigorova Joel A. Swanson Philip D. King Macropinocytosis drives T cell growth by sustaining the activation of mTORC1 Nature Communications
author_facet	John C. Charpentier Di Chen Philip E. Lapinski Jackson Turner Irina Grigorova Joel A. Swanson Philip D. King
author_sort	John C. Charpentier
title	Macropinocytosis drives T cell growth by sustaining the activation of mTORC1
title_short	Macropinocytosis drives T cell growth by sustaining the activation of mTORC1
title_full	Macropinocytosis drives T cell growth by sustaining the activation of mTORC1
title_fullStr	Macropinocytosis drives T cell growth by sustaining the activation of mTORC1
title_full_unstemmed	Macropinocytosis drives T cell growth by sustaining the activation of mTORC1
title_sort	macropinocytosis drives t cell growth by sustaining the activation of mtorc1
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-01-01
description	Macropinocytosis has been implicated in the expansion of transformed cells when nutrient-depleted. Here the authors show that macropinocytosis also contributes to the expansion of primary T cells even under nutrient-replete conditions, potentially by providing access of extracellular amino acids to an endolysosomal compartment to sustain mTORC1 activation.
url	https://doi.org/10.1038/s41467-019-13997-3
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Macropinocytosis drives T cell growth by sustaining the activation of mTORC1

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