Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating

Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating

KATP channels are metabolic sensors that couple cell energetics to membrane excitability. In pancreatic β-cells, channels formed by SUR1 and Kir6.2 regulate insulin secretion and are the targets of antidiabetic sulfonylureas. Here, we used cryo-EM to elucidate structural basis of channel assembly an...

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Bibliographic Details
Main Authors: Gregory M Martin, Craig Yoshioka, Emily A Rex, Jonathan F Fay, Qing Xie, Matthew R Whorton, James Z Chen, Show-Ling Shyng
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-01-01
Series:eLife
Subjects:
ABC transporter
inward rectifier
sulfonylurea receptor
sulfonylurea
ATP
Online Access:https://elifesciences.org/articles/24149

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