Profiling of the plasma proteome across different stages of human heart failure

Heart failure is a major health issue worldwide. Here, Egerstedt et al. perform proteomic profiling of human plasma at different stages of heart failure, providing a comprehensive analysis of changes in the plasma proteome during disease progression.

Bibliographic Details
Main Authors: Anna Egerstedt, John Berntsson, Maya Landenhed Smith, Olof Gidlöf, Roland Nilsson, Mark Benson, Quinn S. Wells, Selvi Celik, Carl Lejonberg, Laurie Farrell, Sumita Sinha, Dongxiao Shen, Jakob Lundgren, Göran Rådegran, Debby Ngo, Gunnar Engström, Qiong Yang, Thomas J. Wang, Robert E. Gerszten, J. Gustav Smith
Format: Article
Language:English
Published: Nature Publishing Group 2019-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-13306-y
id doaj-8631686d85f7447fbe8d13055384ccaf
record_format Article
spelling doaj-8631686d85f7447fbe8d13055384ccaf2021-05-11T12:27:51ZengNature Publishing GroupNature Communications2041-17232019-12-0110111310.1038/s41467-019-13306-yProfiling of the plasma proteome across different stages of human heart failureAnna Egerstedt0John Berntsson1Maya Landenhed Smith2Olof Gidlöf3Roland Nilsson4Mark Benson5Quinn S. Wells6Selvi Celik7Carl Lejonberg8Laurie Farrell9Sumita Sinha10Dongxiao Shen11Jakob Lundgren12Göran Rådegran13Debby Ngo14Gunnar Engström15Qiong Yang16Thomas J. Wang17Robert E. Gerszten18J. Gustav Smith19Department of Cardiology, Clinical Sciences, Lund UniversityDepartment of Cardiology, Clinical Sciences, Lund UniversityDepartment of Cardiothoracic Surgery, Clinical Sciences, Lund University and Skåne University HospitalDepartment of Cardiology, Clinical Sciences, Lund UniversityDepartment of Medicine, Karolinska Institutet and Karolinska University HospitalDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center and Harvard Medical SchoolDivision of Cardiovascular Medicine, Vanderbilt UniversityDepartment of Cardiology, Clinical Sciences, Lund UniversityDepartment of Cardiology, Clinical Sciences, Lund UniversityDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center and Harvard Medical SchoolDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center and Harvard Medical SchoolDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center and Harvard Medical SchoolDepartment of Cardiology, Clinical Sciences, Lund UniversityDepartment of Cardiology, Clinical Sciences, Lund UniversityDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center and Harvard Medical SchoolCardiovascular Epidemiology, Clinical Sciences, Lund UniversityDepartment of Biostatistics, Boston University School of Public HealthDivision of Cardiovascular Medicine, Vanderbilt UniversityDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center and Harvard Medical SchoolDepartment of Cardiology, Clinical Sciences, Lund UniversityHeart failure is a major health issue worldwide. Here, Egerstedt et al. perform proteomic profiling of human plasma at different stages of heart failure, providing a comprehensive analysis of changes in the plasma proteome during disease progression.https://doi.org/10.1038/s41467-019-13306-y
collection DOAJ
language English
format Article
sources DOAJ
author Anna Egerstedt
John Berntsson
Maya Landenhed Smith
Olof Gidlöf
Roland Nilsson
Mark Benson
Quinn S. Wells
Selvi Celik
Carl Lejonberg
Laurie Farrell
Sumita Sinha
Dongxiao Shen
Jakob Lundgren
Göran Rådegran
Debby Ngo
Gunnar Engström
Qiong Yang
Thomas J. Wang
Robert E. Gerszten
J. Gustav Smith
spellingShingle Anna Egerstedt
John Berntsson
Maya Landenhed Smith
Olof Gidlöf
Roland Nilsson
Mark Benson
Quinn S. Wells
Selvi Celik
Carl Lejonberg
Laurie Farrell
Sumita Sinha
Dongxiao Shen
Jakob Lundgren
Göran Rådegran
Debby Ngo
Gunnar Engström
Qiong Yang
Thomas J. Wang
Robert E. Gerszten
J. Gustav Smith
Profiling of the plasma proteome across different stages of human heart failure
Nature Communications
author_facet Anna Egerstedt
John Berntsson
Maya Landenhed Smith
Olof Gidlöf
Roland Nilsson
Mark Benson
Quinn S. Wells
Selvi Celik
Carl Lejonberg
Laurie Farrell
Sumita Sinha
Dongxiao Shen
Jakob Lundgren
Göran Rådegran
Debby Ngo
Gunnar Engström
Qiong Yang
Thomas J. Wang
Robert E. Gerszten
J. Gustav Smith
author_sort Anna Egerstedt
title Profiling of the plasma proteome across different stages of human heart failure
title_short Profiling of the plasma proteome across different stages of human heart failure
title_full Profiling of the plasma proteome across different stages of human heart failure
title_fullStr Profiling of the plasma proteome across different stages of human heart failure
title_full_unstemmed Profiling of the plasma proteome across different stages of human heart failure
title_sort profiling of the plasma proteome across different stages of human heart failure
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-12-01
description Heart failure is a major health issue worldwide. Here, Egerstedt et al. perform proteomic profiling of human plasma at different stages of heart failure, providing a comprehensive analysis of changes in the plasma proteome during disease progression.
url https://doi.org/10.1038/s41467-019-13306-y
work_keys_str_mv AT annaegerstedt profilingoftheplasmaproteomeacrossdifferentstagesofhumanheartfailure
AT johnberntsson profilingoftheplasmaproteomeacrossdifferentstagesofhumanheartfailure
AT mayalandenhedsmith profilingoftheplasmaproteomeacrossdifferentstagesofhumanheartfailure
AT olofgidlof profilingoftheplasmaproteomeacrossdifferentstagesofhumanheartfailure
AT rolandnilsson profilingoftheplasmaproteomeacrossdifferentstagesofhumanheartfailure
AT markbenson profilingoftheplasmaproteomeacrossdifferentstagesofhumanheartfailure
AT quinnswells profilingoftheplasmaproteomeacrossdifferentstagesofhumanheartfailure
AT selvicelik profilingoftheplasmaproteomeacrossdifferentstagesofhumanheartfailure
AT carllejonberg profilingoftheplasmaproteomeacrossdifferentstagesofhumanheartfailure
AT lauriefarrell profilingoftheplasmaproteomeacrossdifferentstagesofhumanheartfailure
AT sumitasinha profilingoftheplasmaproteomeacrossdifferentstagesofhumanheartfailure
AT dongxiaoshen profilingoftheplasmaproteomeacrossdifferentstagesofhumanheartfailure
AT jakoblundgren profilingoftheplasmaproteomeacrossdifferentstagesofhumanheartfailure
AT goranradegran profilingoftheplasmaproteomeacrossdifferentstagesofhumanheartfailure
AT debbyngo profilingoftheplasmaproteomeacrossdifferentstagesofhumanheartfailure
AT gunnarengstrom profilingoftheplasmaproteomeacrossdifferentstagesofhumanheartfailure
AT qiongyang profilingoftheplasmaproteomeacrossdifferentstagesofhumanheartfailure
AT thomasjwang profilingoftheplasmaproteomeacrossdifferentstagesofhumanheartfailure
AT robertegerszten profilingoftheplasmaproteomeacrossdifferentstagesofhumanheartfailure
AT jgustavsmith profilingoftheplasmaproteomeacrossdifferentstagesofhumanheartfailure
_version_ 1721444824635146240