Acute Paraparesis Caused by a Giant Cell Tumor of the Thoracic Spine

• Main Authors: Liang-Chun Chao, Wei-Sheng Juan, Che-Chao Chang, Shih-Huang Tai, Ming-Tsung Chuang, Chun-I Sze, Yu-Chang Hung, E-Jian Lee
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2014-12-01
• Series: Journal of Cancer Research and Practice
• Subjects: acute paraparesis; pathological fracture; spinal giant cell tumor
• Online Access: http://www.sciencedirect.com/science/article/pii/S2311300616300520

Giant cell tumor (GCT) is a benign but locally aggressive skeletal neoplasm of young adults. GCT located in the spine is relatively rare and may need a combination of surgical and adjunctive therapies. Here we present a patient who had intermittent thoracic back pain for two weeks and experienced an acute episode of decreased muscle power of both lower limbs. Magnetic resonance (MR) imaging examinations of the thoracic spine revealed that the patient had severe spinal canal compression caused by pathological fracture due to a tumor within the seventh thoracic vertebra. She underwent an emergent surgical intervention for total removal of the tumor and spinal reconstruction with autologous rib grafts and instruments. Postoperatively, the patient made an uneventful recovery of muscle power of bilateral lower limbs. She subsequently received adjuvant radiotherapy. In a follow-up period of 36 months, the patient had no clinical or radiological evidence of tumor recurrence. Even though spinal location for GCT is a rare event, it should be included in the differential diagnosis in patients with osteolytic lesions or pathological fractures of the vertebra, especially in young female patients sustaining no trauma who had a clinical history of persistent low back pain.