Second-Generation Antimitotics in Cancer Clinical Trials

Second-Generation Antimitotics in Cancer Clinical Trials

Mitosis represents a promising target to block cancer cell proliferation. Classical antimitotics, mainly microtubule-targeting agents (MTAs), such as taxanes and vinca alkaloids, are amongst the most successful anticancer drugs. By disrupting microtubules, they activate the spindle assembly checkpoi...

Full description

Bibliographic Details
Main Authors:	Pedro Novais, Patrícia M. A. Silva, Isabel Amorim, Hassan Bousbaa
Format:	Article
Language:	English
Published:	MDPI AG 2021-07-01
Series:	Pharmaceutics
Subjects:	cancer antimitotics mitotic slippage spindle assembly checkpoint clinical trials
Online Access:	https://www.mdpi.com/1999-4923/13/7/1011

Similar Items

Tumor-Associated Macrophages Suppress the Cytotoxic Activity of Antimitotic Agents
by: Oakley C. Olson, et al.
Published: (2017-04-01)

Prenylated Chalcone 2 Acts as an Antimitotic Agent and Enhances the Chemosensitivity of Tumor Cells to Paclitaxel
by: Joana Fonseca, et al.
Published: (2016-07-01)

Natural products as new antimitotic compounds for anticancer drug development
by: Carlos Roberto Koscky Paier, et al.
Published: (2018-12-01)

Antiproliferative Fate of the Tetraploid Formed after Mitotic Slippage and Its Promotion; A Novel Target for Cancer Therapy Based on Microtubule Poisons
by: Yuji Nakayama, et al.
Published: (2016-05-01)

Effectors of the spindle assembly checkpoint are confined within the nucleus of Saccharomyces cerevisiae
by: Lydia R. Heasley, et al.
Published: (2019-06-01)

Characterizing BUBR1 interactions with MAD2 and p31comet during the Mitotic Checkpoint
by: LaBelle, Jenna J.
Published: (2018)

Complex Commingling: Nucleoporins and the Spindle Assembly Checkpoint
by: Ikram Mossaid, et al.
Published: (2015-11-01)

Identification of novel protein interactors of the SV40 large T antigen using the yeast two hybrid system
by: Cotsiki, Marina
Published: (2002)

Inducing Cellular Senescence in Cancer
by: Restall, Ian J.
Published: (2013)

Inducing Cellular Senescence in Cancer
by: Restall, Ian J.
Published: (2013)

Inducing Cellular Senescence in Cancer
by: Restall, Ian J.
Published: (2013)

The balance between mitotic death and mitotic slippage in acute leukemia: a new therapeutic window?
by: Andrea Ghelli Luserna di Rorà, et al.
Published: (2019-11-01)

Mad2 Overexpression Uncovers a Critical Role for TRIP13 in Mitotic Exit
by: Daniel Henry Marks, et al.
Published: (2017-05-01)

In vitro effects of 2-methoxyestradiol, an endogenous estrogen, on MCF-12A and MCF-7 cell cycle progression
by: Van Zijl, Magdalena Catherina
Published: (2013)

Spindle Architectural Features Must Be Considered Along With Cell Size to Explain the Timing of Mitotic Checkpoint Silencing
by: Mathew Bloomfield, et al.
Published: (2021-01-01)

Potent hemithioindigo-based antimitotics photocontrol the microtubule cytoskeleton in cellulo
by: Alexander Sailer, et al.
Published: (2020-01-01)

Phyllanthus emblica Fruit Extract Activates Spindle Assembly Checkpoint, Prevents Mitotic Aberrations and Genomic Instability in Human Colon Epithelial NCM460 Cells
by: Xihan Guo, et al.
Published: (2016-09-01)

THE FAR C-TERMINUS OF TPX2 CONTRIBUTES TO SPINDLE MORPHOGENESIS
by: Estes, Brett
Published: (2017)

How to Assemble a Functional Mitotic Checkpoint Complex
by: Tipton, Aaron R.
Published: (2012)

In vitro antimitotic and cytotoxic potential of plant extracts: a comparative study of Mucuna pruriens, Asteracantha longifolia and Sphaeranthus indicus
by: Praveen Suresh Gupta, et al.
Published: (2020-12-01)

Investigation of Force, Kinetochores, and Tension in the Saccharomyces Cerevisiae Mitotic Spindle
by: Nannas, Natalie Jo
Published: (2013)

Azetidin-2-ones: structures of antimitotic compounds based on the 1-(3,4,5-trimethoxyphenyl)azetidin-2-one core
by: Brendan Twamley, et al.
Published: (2020-08-01)

Pivoting of microtubules driven by minus-end-directed motors leads to spindle assembly
by: Lora Winters, et al.
Published: (2019-05-01)

PDA Indolylmaleimides Induce Anti-Tumor Effects in Prostate Carcinoma Cell Lines Through Mitotic Death
by: Jan Torben Schille, et al.
Published: (2021-01-01)

In vitro reconstitution of branching microtubule nucleation
by: Ammarah Tariq, et al.
Published: (2020-01-01)

Human kinetochores are swivel joints that mediate microtubule attachments
by: Chris A Smith, et al.
Published: (2016-09-01)

The equatorial position of the metaphase plate ensures symmetric cell divisions
by: Chia Huei Tan, et al.
Published: (2015-07-01)

Application of ensemble pharmacophore-based virtual screening to the discovery of novel antimitotic tubulin inhibitors
by: Laura Gallego-Yerga, et al.
Published: (2021-01-01)

Viriditoxin Stabilizes Microtubule Polymers in SK-OV-3 Cells and Exhibits Antimitotic and Antimetastatic Potential
by: Mingzhi Su, et al.
Published: (2020-08-01)

Deregulation of the spindle assembly checkpoint is associated with paclitaxel resistance in ovarian cancer
by: Taryne Chong, et al.
Published: (2018-04-01)

THE REGULATION OF BubR1 EXPRESSION BY p53: A ROLE FOR p53 IN THE MITOTIC SPINDLE CHECKPOINT AND CHROMOSOME INSTABILITY
by: STUABACH, AMY ELIZABETH
Published: (2004)

Mud binds the kinesin-14 Ncd in Drosophila
by: Vincent Cutillas, et al.
Published: (2021-07-01)

The Kinesin-12 Kif15 is a processive track-switching tetramer
by: Hauke Drechsler, et al.
Published: (2014-03-01)

The Emerging Role of ncRNAs and RNA-Binding Proteins in Mitotic Apparatus Formation
by: Kei K. Ito, et al.
Published: (2020-03-01)

The Arrangement of Microtubules in Embryos Derived from Mice Young, Old and Reconstructed Oocytes
by: A. Shahverdi, et al.
Published: (2008-01-01)

Fancc regulates the spindle assembly checkpoint to prevent tumorigenesis in vivo
by: Edwards, Donna Marie
Published: (2017)

Thymoquinone disrupts the microtubule dynamics in fission yeast <em>Schizosaccharomyces pombe</em>
by: Nusrat Masood, et al.
Published: (2016-11-01)

The spindle assembly checkpoint and speciation
by: Robert C. Jackson, et al.
Published: (2020-05-01)

A Cell Biological Perspective on Past, Present and Future Investigations of the Spindle Assembly Checkpoint
by: Ajit P. Joglekar
Published: (2016-11-01)

A novel mutation in the N-terminal domain of Drosophila BubR1 affects the spindle assembly checkpoint function of BubR1
by: Marie Duranteau, et al.
Published: (2016-11-01)