ZnT8 Deficiency Protects From APAP-Induced Acute Liver Injury by Reducing Oxidative Stress Through Upregulating Hepatic Zinc and Metallothioneins

ZnT8 Deficiency Protects From APAP-Induced Acute Liver Injury by Reducing Oxidative Stress Through Upregulating Hepatic Zinc and Metallothioneins

Zinc transporter 8 (ZnT8) is an important zinc transporter highly expressed in pancreatic islets. Deficiency of ZnT8 leads to a marked decrease in islet zinc, which is thought to prevent liver diseases associated with oxidative stress. Herein, we aimed to investigate whether loss of islet zinc affec...

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Bibliographic Details
Main Authors: Wen Su, Mingji Feng, Yuan Liu, Rong Cao, Yiao Liu, Junyao Tang, Ke Pan, Rongfeng Lan, Zhuo Mao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Pharmacology
Subjects:
ZnT8
acetaminophen
hepatotoxicity
metallothionein
oxidative stress
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.721471/full

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