Gastric mucinous carcinoma with micropapillary carcinoma component: Case report of tumor morphology not previously described in stomach

• Main Authors: Z.M. El-Zaatari, M.R. Schwartz, A.G. Ayala, J.Y. Ro
• Format: Article
• Language: English
• Published: Elsevier 2018-11-01
• Series: Human Pathology: Case Reports
• Online Access: http://www.sciencedirect.com/science/article/pii/S2214330018300804
• ISSN: 2214-3300

Micropapillary (MP) carcinoma is an uncommon tumor with a distinct histologic pattern. Although micropapillary carcinoma has been reported in the stomach, the concurrence of mucinous carcinoma and micropapillary carcinoma has not been reported to-date. A 69-year-old gentleman who presented with anemia was found at endoscopy to have a 1.7 cm gastric ulcer which was biopsied and subsequently underwent a partial gastrectomy. There was an ulcerated moderately differentiated adenocarcinoma displaying a micropapillary component within a mucinous adenocarcinoma component and a metastatic MP carcinoma in 1 of 18 lymph nodes. The tumor was immunoreactive for EMA, MUC2, MUC5AC, MUC6, CDX2, and p53 in both mucinous and mucinous-MP carcinoma areas; and negative for CK7, CK20, CA-125, synaptophysin, chromogranin, PD-L1, MMR proteins, and EBV. To the best of our knowledge, this is the first reported case of MP gastric carcinoma in association with mucinous carcinoma. Key words: Gastric carcinoma, Micropapillary carcinoma, Mucinous carcinoma