Cytoplasmic localization of p21 protects trophoblast giant cells from DNA damage induced apoptosis.

Cytoplasmic localization of p21 protects trophoblast giant cells from DNA damage induced apoptosis.

Proliferating trophoblast stem cells (TSCs) can differentiate into nonproliferating but viable trophoblast giant cells (TGCs) that are resistant to DNA damage induced apoptosis. Differentiation is associated with selective up-regulation of the Cip/Kip cyclin-dependent kinase inhibitors p57 and p21;...

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Bibliographic Details
Main Authors: Christelle de Renty, Melvin L DePamphilis, Zakir Ullah
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4029599?pdf=render

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http://europepmc.org/articles/PMC4029599?pdf=render

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